The Effects of Montelukast on Random Pattern Skin Flap Survival: An Experimental Study in Rats

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dc.authorid0000-0002-4060-3354en_US
dc.contributor.authorGideroğlu, Kaan
dc.contributor.authorYılmaz, Fahrettin
dc.contributor.authorAksoy, Fadullah
dc.contributor.authorBuğdaycı, Güler
dc.contributor.authorÇakıcı, Hüsamettin
dc.contributor.authorHapa, Onur
dc.date.accessioned2021-06-23T19:21:05Z
dc.date.available2021-06-23T19:21:05Z
dc.date.issued2008
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractBACKGROUND: A variety of methods to improve skin flap survival, including the use of pharmacologic agents, have been intensively investigated. Decreasing neutrophil-mediated inflammation and tissue injury has been reported to be effective in improving flap survival. Montelukast is a selective reversible cysteinyl leukotriene receptor-1 antagonist that has been found to have protective effects against renal ischemia reperfusion injury and burn-induced oxidative injury of the skin in rats. However, its effects on skin flap survival have not been previously reported. OBJECTIVE: The aim of this study was to investigate the effects of montelukast on neutrophil-mediated random pattern skin flap survival. METHODS: Mate Sprague-Dawley rats weighing 230 to 250 g were randomly divided into 2 groups-the montelukast-treated group and the control group. Caudally based rectangular random pattern skin flaps 3 x 9 cm were elevated on the backs of the rats. The flaps were sutured into their original places. In the montelukast group, 1 mL of solution containing 10 mg/kg montelukast was administered intraperitoneally (IP) 30 minutes before surgery and then daily for 6 days. In the control group, I mL of saline was administered IP 30 minutes before surgery and then daily for 6 days. To observe the effects of montelukast, myeloperoxidase (MPO) activity, an index of tissue neutrophil infiltration, was measured from extracted skin tissue 12 hours after flap elevation. Flap viability was evaluated 7 days after surgery by measuring necrotic flap area and total flap area. RESULTS: Sixteen rats (mean [SD] weight, 240.6 [6.6] g) were equally divided between the 2 groups. All rats survived throughout the study period. Mean (SD) MPO activity in flap tissue was significantly lower in the montelukast group than in the control group (14.57 [2.33] vs 21.28 [4.86] U/g protein; P = 0.005). The percentage of necrotic flap area was significantly lower in the montelukast group than in the control group (17.17 [7-95] vs 37.51 [10.72]; P = 0.001). CONCLUSION: This small, experimental, in vivo animal study found that montelukast was associated with both lower MPO activity and a lower percentage of necrotic random pattern skin flap area. Future studies are needed to clarify these findings. (Curr Ther Res Clin Exp. 2008;69:459-465) (C) 2008 Excerpta Medica Inc.en_US
dc.identifier.doi10.1016/j.curtheres.2008.10.003
dc.identifier.endpage465en_US
dc.identifier.issn0011-393X
dc.identifier.issn1879-0313
dc.identifier.issue5en_US
dc.identifier.pmid24692820en_US
dc.identifier.scopus2-s2.0-58149385204en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage459en_US
dc.identifier.urihttps://doi.org/10.1016/j.curtheres.2008.10.003
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6213
dc.identifier.volume69en_US
dc.identifier.wosWOS:000261043200006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGideroğlu, Kaan
dc.institutionauthorYılmaz, Fahrettin
dc.institutionauthorBuğdaycı, Güler
dc.institutionauthorÇakıcı, Hüsamettin
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofCurrent Therapeutic Research-Clinical And Experimentalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMontelukasten_US
dc.subjectSkin Flap Survivalen_US
dc.subjectNecrosisen_US
dc.titleThe Effects of Montelukast on Random Pattern Skin Flap Survival: An Experimental Study in Ratsen_US
dc.typeArticleen_US

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