The Effects of Montelukast on Random Pattern Skin Flap Survival: An Experimental Study in Rats
dc.authorid | 0000-0002-4060-3354 | en_US |
dc.contributor.author | Gideroğlu, Kaan | |
dc.contributor.author | Yılmaz, Fahrettin | |
dc.contributor.author | Aksoy, Fadullah | |
dc.contributor.author | Buğdaycı, Güler | |
dc.contributor.author | Çakıcı, Hüsamettin | |
dc.contributor.author | Hapa, Onur | |
dc.date.accessioned | 2021-06-23T19:21:05Z | |
dc.date.available | 2021-06-23T19:21:05Z | |
dc.date.issued | 2008 | |
dc.department | BAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü | en_US |
dc.department | BAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü | |
dc.description.abstract | BACKGROUND: A variety of methods to improve skin flap survival, including the use of pharmacologic agents, have been intensively investigated. Decreasing neutrophil-mediated inflammation and tissue injury has been reported to be effective in improving flap survival. Montelukast is a selective reversible cysteinyl leukotriene receptor-1 antagonist that has been found to have protective effects against renal ischemia reperfusion injury and burn-induced oxidative injury of the skin in rats. However, its effects on skin flap survival have not been previously reported. OBJECTIVE: The aim of this study was to investigate the effects of montelukast on neutrophil-mediated random pattern skin flap survival. METHODS: Mate Sprague-Dawley rats weighing 230 to 250 g were randomly divided into 2 groups-the montelukast-treated group and the control group. Caudally based rectangular random pattern skin flaps 3 x 9 cm were elevated on the backs of the rats. The flaps were sutured into their original places. In the montelukast group, 1 mL of solution containing 10 mg/kg montelukast was administered intraperitoneally (IP) 30 minutes before surgery and then daily for 6 days. In the control group, I mL of saline was administered IP 30 minutes before surgery and then daily for 6 days. To observe the effects of montelukast, myeloperoxidase (MPO) activity, an index of tissue neutrophil infiltration, was measured from extracted skin tissue 12 hours after flap elevation. Flap viability was evaluated 7 days after surgery by measuring necrotic flap area and total flap area. RESULTS: Sixteen rats (mean [SD] weight, 240.6 [6.6] g) were equally divided between the 2 groups. All rats survived throughout the study period. Mean (SD) MPO activity in flap tissue was significantly lower in the montelukast group than in the control group (14.57 [2.33] vs 21.28 [4.86] U/g protein; P = 0.005). The percentage of necrotic flap area was significantly lower in the montelukast group than in the control group (17.17 [7-95] vs 37.51 [10.72]; P = 0.001). CONCLUSION: This small, experimental, in vivo animal study found that montelukast was associated with both lower MPO activity and a lower percentage of necrotic random pattern skin flap area. Future studies are needed to clarify these findings. (Curr Ther Res Clin Exp. 2008;69:459-465) (C) 2008 Excerpta Medica Inc. | en_US |
dc.identifier.doi | 10.1016/j.curtheres.2008.10.003 | |
dc.identifier.endpage | 465 | en_US |
dc.identifier.issn | 0011-393X | |
dc.identifier.issn | 1879-0313 | |
dc.identifier.issue | 5 | en_US |
dc.identifier.pmid | 24692820 | en_US |
dc.identifier.scopus | 2-s2.0-58149385204 | en_US |
dc.identifier.scopusquality | Q3 | en_US |
dc.identifier.startpage | 459 | en_US |
dc.identifier.uri | https://doi.org/10.1016/j.curtheres.2008.10.003 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12491/6213 | |
dc.identifier.volume | 69 | en_US |
dc.identifier.wos | WOS:000261043200006 | en_US |
dc.identifier.wosquality | Q4 | en_US |
dc.indekslendigikaynak | Web of Science | en_US |
dc.indekslendigikaynak | Scopus | en_US |
dc.indekslendigikaynak | PubMed | en_US |
dc.institutionauthor | Gideroğlu, Kaan | |
dc.institutionauthor | Yılmaz, Fahrettin | |
dc.institutionauthor | Buğdaycı, Güler | |
dc.institutionauthor | Çakıcı, Hüsamettin | |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Science Inc | en_US |
dc.relation.ispartof | Current Therapeutic Research-Clinical And Experimental | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Montelukast | en_US |
dc.subject | Skin Flap Survival | en_US |
dc.subject | Necrosis | en_US |
dc.title | The Effects of Montelukast on Random Pattern Skin Flap Survival: An Experimental Study in Rats | en_US |
dc.type | Article | en_US |
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