Is neuregulin-4 a predictive marker of microvascular complications in type 2 diabetes mellitus?

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dc.authorid0000-0002-7006-3125en_US
dc.authorid0000-0001-7306-5233en_US
dc.authorid0000-0003-3085-7964en_US
dc.authorid0000-0002-3836-2125
dc.contributor.authorKoçak, Mehmet Zahid
dc.contributor.authorAktaş, Gülali
dc.contributor.authorTel, Meryem Burçin Atak
dc.contributor.authorDuman, Tuba Taslamacıoğlu
dc.contributor.authorYis, Özgür Mehmet
dc.contributor.authorErkuş, Edip
dc.contributor.authorŞavlı, Haluk
dc.date.accessioned2021-06-23T19:54:31Z
dc.date.available2021-06-23T19:54:31Z
dc.date.issued2020
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground and Aims Neuregulin-4 (Nrg-4) is a new adipokine released from brown adipose tissue. It plays pivotal role in regulating systemic energy balance, glucose and lipid metabolism and in reducing chronic inflammation. We aimed to investigate the relation between diabetic microvascular complications (DMC) and serum (Nrg-4) levels in patients with type 2 diabetes mellitus. Methods Patients with type 2 diabetes mellitus were divided into DMC and diabetic patients without microvascular complications (non-DMC). Nrg-4 levels of the patients were compared. Results Fifty and 29 patients enrolled to the DMC and non-DMC groups, respectively. Nrg-4 was 1.23 (0.02-5.1) ng/mL and 2.5 (0.21-6.01) ng/mL in DMC and in non-DMC groups, respectively (P < .001). In patients with DMC, FPG was 189.5 (89-446) mg/ dL, whereas it was 128 (95-278) mg/dL in non-DMC diabetic patients (P < .001). HbA1c was also significantly higher in the DMC group than in the non-DMC group (P < .001). Negative correlation was found between Nrg-4 and FPG (r = -0.231, P = .03), HBA1c (r = -0.312, P = .003) and microalbuminuria (r = -0.277, P = .009). Logistic regression analysis showed a 1-unit decrease in Nrg-4 to increase the presence of DMC by 1.9 times. The best cut-off value of Nrg-4 was 1.56 ng/mL with 82.1% sensitivity and 64% specificity, in predicting DMC. Conclusion In patients with diabetes, Nrg-4 levels may be a good predictor of early detection of one or more DMC, as microvascular dysfunction in an organ system is considered to be an initial onset of subclinical systemic damage.en_US
dc.identifier.doi10.1111/eci.13206
dc.identifier.issn0014-2972
dc.identifier.issn1365-2362
dc.identifier.issue3en_US
dc.identifier.pmid31999832en_US
dc.identifier.scopus2-s2.0-85079728190en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1111/eci.13206
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10570
dc.identifier.volume50en_US
dc.identifier.wosWOS:000513381400001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKoçak, Mehmet Zahid
dc.institutionauthorAktaş, Gülali
dc.institutionauthorTel, Meryem Burçin Atak
dc.institutionauthorDuman, Tuba Taslamacıoğlu
dc.institutionauthorErkuş, Edip
dc.institutionauthorYis, Özgür Mehmet
dc.institutionauthorŞavlı, Haluk
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofEuropean Journal Of Clinical Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMicrovascular Complicationen_US
dc.subjectNephropathyen_US
dc.subjectNeuregulin-4en_US
dc.subjectNeuropathyen_US
dc.subjectRetinopathyen_US
dc.subjectType 2 Diabetes Mellitusen_US
dc.titleIs neuregulin-4 a predictive marker of microvascular complications in type 2 diabetes mellitus?en_US
dc.typeArticleen_US

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