Effect of epidural levobupivacaine and levobupivacaine with fentanyl on stress response and postoperative analgesia after total knee replacement

dc.authorid0000-0003-0582-8723
dc.contributor.authorBayazit, Esra Gümüş
dc.contributor.authorKaraaslan, Kazım
dc.contributor.authorÖzturan, Kutay
dc.contributor.authorSerin, Erdinç
dc.contributor.authorKocoğlu, Hasan
dc.date.accessioned2021-06-23T19:34:22Z
dc.date.available2021-06-23T19:34:22Z
dc.date.issued2013
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Providing sufficient and convenient analgesia is crucial during the postoperative period after total-knee replacement (TKR) to enhance patient mobility and reduce stress response to surgery. The scope of this study is to compare the effects of levobupivacaine and levobupivacaine plus fentanyl on stress response and analgesic efficiency after TKR. Method: In this study, 40 ASA I - II patients scheduled to undergo TKR were subjected to combined spinal epidural anesthesia (CSEA) injecting of 15 mg levobupivacaine and randomly assigned to receive either levobupivacaine 0.125% (Group L) or levobupivacaine 0.125% plus fentanyl 4 mu g ml(-1) (Group F) during postoperative period via the epidural route. Patient controlled epidural analgesia (PCEA) was offered for 24 hours. Venous blood samples were assayed for ach-enocorticotropic hormone (ACTH), cortisol and prolactin levels before surgery and after analgesia administration. Analgesia was assessed using a visual analogue scale (VAS) at rest (VASR) and during movement (VASM). Results: There was no statistically significant difference between the groups in terms of total doses, bolus requests, bolus delivered and side effects (p > 0.05). The ACTH, cortisol and prolactin levels increased following the surgery and decreased during PCA infusion in both groups where the decline in Group F was significant (p < 0.05) at 24 hours after the analgesic treatment and 48 hours after the surgery. Conclusion: We have demonstrated that infusion of levobupivacaine (0.125%) in combination with fentanyl (4 jig ml-1) using PCEA suppressed stress response to surgery significantly and provided better pain relief than levobupivacaine (0.125%) alone after TKR.en_US
dc.identifier.doi10.5414/CP201862
dc.identifier.endpage659en_US
dc.identifier.issn0946-1965
dc.identifier.issue8en_US
dc.identifier.pmid23782581en_US
dc.identifier.scopus2-s2.0-84883173812en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage652en_US
dc.identifier.urihttps://doi.org/10.5414/CP201862
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7485
dc.identifier.volume51en_US
dc.identifier.wosWOS:000323990300005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBayazit, Esra Gümüş
dc.institutionauthorÖzturan, Kutay
dc.institutionauthorSerin, Erdinç
dc.institutionauthorKocoğlu, Hasan
dc.language.isoenen_US
dc.publisherDustri-Verlag Dr Karl Feistleen_US
dc.relation.ispartofInternational Journal Of Clinical Pharmacology And Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdjuvantsen_US
dc.subjectAnesthesiaen_US
dc.subjectFentanylen_US
dc.subjectAnalgesiaen_US
dc.subjectPatient-controlleden_US
dc.subjectAnestheticsen_US
dc.subjectLocalen_US
dc.subjectLevobupivacaineen_US
dc.subjectArthroplastyen_US
dc.subjectReplacementen_US
dc.subjectKneeen_US
dc.subjectPainen_US
dc.subjectPostoperativeen_US
dc.subjectSurgery Stressen_US
dc.subjectResponseen_US
dc.titleEffect of epidural levobupivacaine and levobupivacaine with fentanyl on stress response and postoperative analgesia after total knee replacementen_US
dc.typeArticleen_US

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