Anti-inflammatory potential of liraglutide, a glucagon-like peptide-1 receptor agonist, in rats with peripheral acute inflammation

dc.authorid0000-0003-0501-5677en_US
dc.authorid0000-0002-8212-7149en_US
dc.authorid0000-0001-9532-8241en_US
dc.authorid0000-0001-8791-235Xen_US
dc.authorid0000-0002-3394-2438en_US
dc.authorid0000-0001-7035-3336en_US
dc.authorid0000-0001-9865-1685en_US
dc.contributor.authorMert, İrem
dc.contributor.authorÇetinkaya, Ayhan
dc.contributor.authorGürler, Müjgan
dc.contributor.authorTürel, Canan Akünal
dc.contributor.authorÇelik, Hümeyra
dc.contributor.authorTorun, İbrahim Ethem
dc.contributor.authorTürel, İdris
dc.date.accessioned2023-12-05T11:50:13Z
dc.date.available2023-12-05T11:50:13Z
dc.date.issued2022en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionThis study was supported by the Bolu Abant Izzet Baysal University Scientific Research Fund (Grant number 2021.08.36.1497).en_US
dc.description.abstractThe present study aimed to explore the possible anti-inflammatory actions of liraglutide (LRG), a glucagon-like peptide-1 (GLP-1) receptor agonist, and to compare with tramadol (TR) or LRG, and TR combination treatment by investigating the inflammatory signs such as pain hypersensitivity, edema, and fever in carrageenan (CG)-induced acute peripheral inflammation model in rats. The levels of several biomarkers for inflammatory status, angiogenesis, and oxidative stress were also measured in inflamed tissues. CG induced inflammation in the paws of rats identified by hypersensitivities, redness, edema and fever. LRG, significantly improved the hypersensitivity to mechanical (from 4 to 35.5 g) or cold (from 5 to 44.2 s) stimuli, reduced the edema (paw mass, from 2.54 to 1.85 g), and fever (paw temperature, from 33.6 to 27.3 degrees C). LRG dramatically suppressed the inflammatory signs when compared to those of TR. In addition, co-administration of TR and LRG resulted in further reduction of sensitivity to mechanical and cold stimuli. Anti-inflammatory potential of LRG altered depending on their inhibitory effects in the biomarkers of inflamed paws. Consequently, the suppressive actions of LRG in the inflammation induced hypersensitivities, edema, and fever, indicating that these drugs have significant anti-inflammatory potential with anti-hypersensitivities, anti-edema, and anti-pyretic effects. LRG with anti-inflammatory actions may be a highly promising therapeutic option for the management of inflammatory conditions or inflammatory-related various diseases.en_US
dc.description.sponsorshipBolu Abant Izzet Baysal University Scientific Research Fund [2021.08.36.1497]en_US
dc.identifier.citationMert, I., Cetinkaya, A., Gurler, M., Turel, C. A., Celik, H., Torun, I. E., & Turel, I. (2022). Anti-inflammatory potential of liraglutide, a glucagon-like peptide-1 receptor agonist, in rats with peripheral acute inflammation. Inflammopharmacology, 30(3), 1093-1105.en_US
dc.identifier.doi10.1007/s10787-022-00978-0
dc.identifier.endpage1105en_US
dc.identifier.issn0925-4692
dc.identifier.issn1568-5608
dc.identifier.issue3en_US
dc.identifier.pmid35412166en_US
dc.identifier.scopus2-s2.0-85127952083en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1093en_US
dc.identifier.urihttp://dx.doi.org/10.1007/s10787-022-00978-0
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11895
dc.identifier.volume30en_US
dc.identifier.wosWOS:000781709900001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÇetinkaya, Ayhan
dc.institutionauthorGürler, Müjgan
dc.institutionauthorTürel, Canan Akünal
dc.institutionauthorTorun, İbrahim Ethem
dc.institutionauthorTürel, İdris
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInflammopharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLiraglutideen_US
dc.subjectTramadolen_US
dc.subjectHypersensitivityen_US
dc.subjectTramadolen_US
dc.subjectMechanismsen_US
dc.subjectAllodyniaen_US
dc.titleAnti-inflammatory potential of liraglutide, a glucagon-like peptide-1 receptor agonist, in rats with peripheral acute inflammationen_US
dc.typeArticleen_US

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