Protective effects of intraperitoneal vitamin c, aprotinin and melatonin administration on retinal edema during experimental uveitis in the guinea pig

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dc.authorid0000-0001-5387-2628
dc.authorid0000-0003-0887-6974
dc.authorid0000-0003-1364-4684
dc.authorid0000-0001-8305-6600
dc.authoridAydemir, Orhan
dc.contributor.authorKükner, A. Şahap
dc.contributor.authorKükner, Aysel
dc.contributor.authorNazıroğlu, Mustafa
dc.contributor.authorÇolakoğlu, Neriman
dc.contributor.authorÇelebi, Serdal
dc.contributor.authorYılmaz, Turgut
dc.contributor.authorAydemir, Orhan
dc.date.accessioned2021-06-23T19:17:52Z
dc.date.available2021-06-23T19:17:52Z
dc.date.issued2004
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü
dc.description.abstractA considerable amount of clinical and experimental evidence exists suggesting the involvement of reactive oxygen substances (ROS) in the actiology of uveitis. The activated phagocytic system of polymorphonuclear leucocytes in uveitis is involved in the generation of ROS. In addition to their direct free radical scavenging action, aprotinin, melatonin and vitamin C are known to protect against oedema formation and can preserve plasma membrane fluidity and free radical production. Histological changes in the retina that occur during uveitis are not well explained. The purpose of this study was to determine whether vitamin C, aprotinin and melatonin can protect the retina from damage accompanying experimental uveitis (EU). Thirty adult male guinea pigs were divided into five groups of six animals each. The first group was used as control. The right eyes of groups 2, 3, 4 and 5 received an intravitreal injection of bovine serum albumin for induction of experimental uveitis. At the same time and also on the consecutive third day, groups 3, 4 and 5 received intraperitoneal injections of vitamin C (ascorbic acid, 100 mg kg(-1) body wt), aprotinin (20 000 mg kg(-1) body wt) and melatonin (10 mg kg(-1) body wt), respectively. The animals were killed on the sixth day. The average thickness of the retina and inner plexiform layer for each eye was measured in sagittal section near the optic nerve and expressed in microns. The thickness of the retina and inner plexiform layer in the control group was significantly (p < 0.01) lower than in the group EU as compared with the group EU plus vitamin C, group EU plus aprotinin, group EU plus melatonin (p < 0.05). The thicknesses of the retina and inner plexiform layer in group EU plus vitamin C, group EU plus aprotinin and group EU plus melatonin were significantly (p < 0 01) lower than that in the group EU. The difference in thickness of the retina and inner plexiform layer among the groups 3, 4 and 5 was not significant (p > 0.05). In conclusion, this study demonstrated that oedematous effects of EU on the retina were reduced by the administration of intraperitoneal vitamin C, aprotinin and melatonin, i.e. these antioxidants had significant protective effects on the retina of guinea pigs against oedematous damage in EU. However, the reductive effect of vitamin C on EU was greater than that of aprotinin and melatonin. The intraperitoneal vitamin C, aprotinin and melatonin supplementations may strengthen the antioxidant defence system because of decreased ROS, and these agents may play a role in treating uveitis.en_US
dc.identifier.doi10.1002/cbf.1105
dc.identifier.endpage305en_US
dc.identifier.issn0263-6484
dc.identifier.issue5en_US
dc.identifier.pmid15338469en_US
dc.identifier.scopus2-s2.0-4444353682en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage299en_US
dc.identifier.urihttps://doi.org/10.1002/cbf.1105
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5569
dc.identifier.volume22en_US
dc.identifier.wosWOS:000223881800005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKükner, A. Şahap
dc.institutionauthorKükner, Aysel
dc.institutionauthorÇelebi, Serdal
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofCell Biochemistry And Functionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEUen_US
dc.subjectExperimental Uveitisen_US
dc.subjectBSAen_US
dc.subjectBovine Serum Albuminen_US
dc.subjectROSen_US
dc.subjectReactive Oxygen Substancesen_US
dc.subjectPMNen_US
dc.subjectPolymorphonuclear Leucocytesen_US
dc.titleProtective effects of intraperitoneal vitamin c, aprotinin and melatonin administration on retinal edema during experimental uveitis in the guinea pigen_US
dc.typeArticleen_US

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