Antiproliferative activity of some medicinal plants on human breast and hepatocellular carcinoma cell lines and their phenolic contents

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dc.authorid0000-0001-7712-2813en_US
dc.authorid0000-0002-5650-1280
dc.authorid0000-0001-5245-6294
dc.contributor.authorKarakaş, Fatma Pehlivan
dc.contributor.authorYıldırım, Arzu Birinci
dc.contributor.authorBayram, Recep
dc.contributor.authorYavuz, Muhsine Z.
dc.contributor.authorGepdiremen, Akçahan
dc.contributor.authorTürker, Arzu Uçar
dc.date.accessioned2021-06-23T19:37:34Z
dc.date.available2021-06-23T19:37:34Z
dc.date.issued2015
dc.departmentBAİBÜ, Ziraat Fakültesi, Tarla Bitkileri Bölümüen_US
dc.description.abstractPurpose: To determine the phenolic composition and antiproliferative activity of 16 different extracts (hexane, dichloromethane, methanol and water) obtained from Bellis perennis, Convolvulus galaticus, Trifolium pannonicum and Lysimachia vulgaris on human breast cancer (MCF-7) and human hepatocellular carcinoma (HepG2/C3A) cell lines. Methods: The aerial parts of the plants were successively extracted with hexane, dichloromethane, methanol and water using a Soxhlet apparatus. The phenolic content of the plants were determined by plants by high performance liquid chromatography (HPLC) while their antiproliferative activity was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide, a yellow tetrazole (MTT) assay. Results: Among the tested extracts, the methanol extract of B. perennis showed the best antiproliferative activity against MCF-7 cell line with IC50 (inhibiting 50 % of cell growth) value of 71.6 mu g/mL. Furthermore, the dichloromethane extract of C. galaticus showed the best anti-proliferative activity against HepG2/C3A cell line with IC50 of 57.3 mu g/mL. The HPLC data for the plant extracts showed the presence of the following phenolic compounds: gallic acid monohydrate, caffeic acid, rutin hydrate, luteolin-7-O-beta-D glucoside, kaempferol, myricetin, quercetin, coumarin and apigenin. Conclusion: The findings of this study indicate that there is some justification for the use of B. perennis and C. galaticus as traditional anticancer medicinal herbs.en_US
dc.identifier.doi10.4314/tjpr.v14i10.8
dc.identifier.endpage1795en_US
dc.identifier.issn1596-5996
dc.identifier.issue10en_US
dc.identifier.scopus2-s2.0-84946090492en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1787en_US
dc.identifier.urihttps://doi.org/10.4314/tjpr.v14i10.8
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8179
dc.identifier.volume14en_US
dc.identifier.wosWOS:000366915900007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorKarakaş, Fatma Pehlivan
dc.institutionauthorYıldırım, Arzu Birinci
dc.institutionauthorBayram, Recep
dc.institutionauthorYavuz, Muhsine Z.
dc.institutionauthorGepdiremen, Akçahan
dc.institutionauthorTürker, Arzu Uçar
dc.language.isoenen_US
dc.publisherPharmacotherapy Groupen_US
dc.relation.ispartofTropical Journal Of Pharmaceutical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBellis Perennisen_US
dc.subjectConvolvulus Galaticusen_US
dc.subjectTrifolium Pannonicum Subsp Elongatumen_US
dc.subjectLysimachia Vulgarisen_US
dc.subjectMCF-7en_US
dc.subjectHepG2/C3Aen_US
dc.subjectPhenolicsen_US
dc.subjectBreast Canceren_US
dc.subjectAntiproliferativeen_US
dc.titleAntiproliferative activity of some medicinal plants on human breast and hepatocellular carcinoma cell lines and their phenolic contentsen_US
dc.typeArticleen_US

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