Electrophysiologic and anti-inflammatorial effects of cyclooxygenase inhibition in epileptiform activity

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dc.authorid0000-0001-8791-235Xen_US
dc.authorid0000-0002-3394-2438en_US
dc.authorid0000-0002-8212-7149en_US
dc.authorid0000-0001-9865-1685en_US
dc.contributor.authorTürel, Canan Akünal
dc.contributor.authorÇelik, Hümeyra
dc.contributor.authorÇetinkaya, Ayhan
dc.contributor.authorTürel, İdris
dc.date.accessioned2024-07-30T12:50:21Z
dc.date.available2024-07-30T12:50:21Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionAbant Izzet Baysal UEniversitesi, Grant/Award Number: 2021.08.32.1488.en_US
dc.description.abstractThe aim of our study is to investigate the electrophysiological and anti-inflammatory effects of diclofenac potassium on epileptiform activity, which is the liquid form of diclofenac, and frequently used clinically for inflammatory process by inhibiting cyclooxygenase enzyme (COX). Wistar rats aged 2-4 months were divided into Epilepsy, Diazepam, Diclofenac potassium, and Diazepam+diclofenac potassium groups. Diazepam and diclofenac potassium were administered intraperitoneally 30 min after the epileptiform activity was created with penicillin injected intracortically under anesthesia. After the electrophysiological recording was taken in the cortex for 125 min, interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) were evaluated by the ELISA in the serums. No change was observed between the groups in serum IL-1 beta, IL-6, and TNF-alpha values. It was observed that the co-administration of diclofenac potassium and diazepam at 51-55, 56-60, 61-65, 111-115, and 116-120 min was more effective in reducing spike amplitude than diclofenac potassium alone (p < 0.05). Single-dose diclofenac potassium did not have an anti-inflammatory effect in epileptiform activity but both diazepam and diclofenac potassium reduced the epileptiform activity.en_US
dc.description.sponsorshipAbant Izzet Baysal UEniversitesi [2021.08.32.1488]en_US
dc.identifier.citationAkunal Türel, C., Çelik, H., Çetinkaya, A., & Türel, İ. (2023). Electrophysiologic and anti‐inflammatorial effects of cyclooxygenase inhibition in epileptiform activity. Physiological Reports, 11(17), e15800.en_US
dc.identifier.doi10.14814/phy2.15800
dc.identifier.endpage9en_US
dc.identifier.issn2051-817X
dc.identifier.issue17en_US
dc.identifier.pmid37688418en_US
dc.identifier.scopus2-s2.0-85170270127en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttp://dx.doi.org/10.14814/phy2.15800
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12289
dc.identifier.volume11en_US
dc.identifier.wosWOS:001064442500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTürel, Canan Akünal
dc.institutionauthorÇetinkaya, Ayhan
dc.institutionauthorTürel, İdris
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPhysiological Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute Seizureen_US
dc.subjectAnti-Inflammatoryen_US
dc.subjectDiclofenac Potassiumen_US
dc.subjectPenicillinen_US
dc.subjectSeizuresen_US
dc.subjectDiclofenacen_US
dc.titleElectrophysiologic and anti-inflammatorial effects of cyclooxygenase inhibition in epileptiform activityen_US
dc.typeArticleen_US

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