Serum cortisol levels following acute experimental spinal cord injury

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dc.authorid0000-0002-0437-5075
dc.contributor.authorGezici, Ali Rıza
dc.contributor.authorKarakaş, Alper
dc.contributor.authorErgün, Rüçhan
dc.contributor.authorGündüz, Bülent
dc.date.accessioned2021-06-23T19:26:12Z
dc.date.available2021-06-23T19:26:12Z
dc.date.issued2009
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground and purpose: Cortisol has neuroprotective effects. We monitored the serum cortisol levels after cervical and thoracic spinal cord injury (SCI) in four groups of rats. Materials and methods: Forty male Sprague-Dawley rats were randomized to four groups. The control group received neither laminectomy nor SCI. The sham group received laminectomy without SCT. The cervical spinal trauma group received a C5-C6 laminectomy and spinal trauma at this level. The thoracic spinal trauma group received a T6-T7 laminectomy and spinal trauma. Blood samples were drawn 2, 6, 12 and 24 hours after surgeries and assayed immediately. Results: The level of cortisol in the cervical spinal trauma group was highest at the second hour of the experiment and the lowest in control and sham-operated groups at the same time. At the sixth hour, cortisol levels increased in control and sham operated groups decreased, but increased in thoracic and cervical groups decreased, but increased in thoracic and cervical groups. After the 24(th) hour, serum cortisol levels in thoracic and cervical groups decreased but did not change significantly in control and sham-operated animals. Conclusion: Activation of endogen cortisol secretion of the organism starts immediately after the SCI injury and throughout the experiment the serum cortisol levels in neurotrauma groups remained high compared with the control and sham-operated groups. At the beginning, the level of neurological lesion (cervical or thoracic) affected differently the level of serum cortisol at a statistically significant level but this difference disappeared at the 6(th) hour.en_US
dc.identifier.endpage357en_US
dc.identifier.issn0028-3843
dc.identifier.issue4en_US
dc.identifier.pmid19742394en_US
dc.identifier.scopus2-s2.0-70449719189en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage352en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6456
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-70449719189&partnerID=40&md5=c5d0619479fe8cd993e117b14268ced9
dc.identifier.volume43en_US
dc.identifier.wosWOS:000271451600005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGezici, Ali Rıza
dc.institutionauthorKarakaş, Alper
dc.institutionauthorErgün, Rüçhan
dc.language.isoenen_US
dc.publisherElsevier Urban & Partner Sp Z O Oen_US
dc.relation.ispartofNeurologia I Neurochirurgia Polskaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCortisolen_US
dc.subjectNeuroprotectionen_US
dc.subjectSpinal Cord Injuryen_US
dc.subjectELISAen_US
dc.titleSerum cortisol levels following acute experimental spinal cord injuryen_US
dc.typeArticleen_US

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