Effect of methylphenidate at different doses on new bone formation with rapid maxillary expansion: A micro-CT and histomorphometric study in rats

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dc.authorid0000-0002-1488-616Xen_US
dc.authorid0000-0001-6768-1275en_US
dc.authorid0000-0001-9540-9906en_US
dc.authorid0000-0002-3537-0138en_US
dc.contributor.authorDursun, Saffet
dc.contributor.authorErhamza, T. Sezen
dc.contributor.authorÖnder, Mustafa Ercüment
dc.contributor.authorDüzcü, Selma Erdoğan
dc.date.accessioned2023-07-14T08:41:09Z
dc.date.available2023-07-14T08:41:09Z
dc.date.issued2022en_US
dc.departmentBAİBÜ, Diş Hekimliği Fakültesi, Ortodonti Ana Bilim Dalıen_US
dc.descriptionScientific and Technological Research Council of Turkey (TUBITAK)(Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK))en_US
dc.description.abstractObjectives This study aimed to evaluate the effect of systemically administered methylphenidate hydrochloride (MPH) on new bone formation in premaxillary suture after rapid maxillary expansion (RME). Setting and Sample Population Thirty-three Wistar rats were divided into four groups: Group 1 (high dose, 30/60 mg/kg MPH), Group 2 (low dose, 4/10 mg/kg MPH), Group 3 (positive control) and Group 4 (negative control). Methods RME was applied on the 70th day of the study. A 5-day RME period was followed by a 12-day retention period. The experiment was terminated on the 87th day. Micro-CT for radiological evaluation, haematoxylin-eosin and Masson's trichrome staining methods were used for histomorphometric evaluation. Results Among experimental groups with RME, the lowest number of osteoblasts and capillaries in Group 1 (P < .05). New bone formation, fibrous callus formation, distal osteotomy line, proximal osteotomy union and cortex remodelling were observed to be lower in Group 1 and Group 2 than Group 3 (P < .05). There was a statistically significant difference between Group 4 and each of the other groups (P = .000) in the evaluation of the results for bone mineral density, bone volume, bone volume percentage, trabecular thickness and trabecular number. Conclusions MPH reduces cellular activity for new bone formation in suture in RME groups. Before performing rapid maxillary expansion in patients using MPH, the use of the drug should be postponed after a multidisciplinary decision process or clinical doses should be lowered.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [118S720]en_US
dc.identifier.citationDursun, S., Sezen Erhamza, T., Önder, M. E., & Erdoğan Düzcü, S. (2022). Effect of methylphenidate at different doses on new bone formation with rapid maxillary expansion: A micro‐CT and histomorphometric study in rats. Orthodontics & Craniofacial Research, 25(3), 384-392.en_US
dc.identifier.doi10.1111/ocr.12547
dc.identifier.endpage392en_US
dc.identifier.issn1601-6335
dc.identifier.issn1601-6343
dc.identifier.issue3en_US
dc.identifier.pmid34821040en_US
dc.identifier.scopus2-s2.0-85120087146en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage384en_US
dc.identifier.urihttp://dx.doi.org/10.1111/ocr.12547
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11288
dc.identifier.volume25en_US
dc.identifier.wosWOS:000723365500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDursun, Saffet
dc.institutionauthorDüzcü, Selma Erdoğan
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofOrthodontics & Craniofacial Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.relation.tubitakScientific and Technological Research Council of Turkey (TUBITAK) [118S720]
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMethylphenidateen_US
dc.subjectNew Bone Formationen_US
dc.subjectRapid Maxillary Expansionen_US
dc.subjectDeficit Hyperactivity Disorderen_US
dc.subjectMid-Palatal Sutureen_US
dc.subjectMidpalatal Sutureen_US
dc.titleEffect of methylphenidate at different doses on new bone formation with rapid maxillary expansion: A micro-CT and histomorphometric study in ratsen_US
dc.typeArticleen_US

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