Protective effects of montelukast and Hypericum perforatum against intestinal ischemia-reperfusion injury in hamsters

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dc.authorid0000-0002-4552-0048
dc.authorid0000-0001-8590-4831
dc.contributor.authorOcak, Tarık
dc.contributor.authorDuran, Arif
dc.contributor.authorÖzyalvaçlı, Gülzade
dc.contributor.authorOcak, Zeynep
dc.contributor.authorTerzi, Elçin Hakan
dc.contributor.authorTosun, Mehmet
dc.contributor.authorErdem, Kemalettin
dc.date.accessioned2021-06-23T18:40:26Z
dc.date.available2021-06-23T18:40:26Z
dc.date.issued2014
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractAim: To evaluate the effects of montelukast and Hypericum perforatum against ischemia/reperfusion (I/R)-induced intestinal damage. Materials and methods: Twenty-eight hamsters were divided into 4 groups following midline abdominal laparotomy: control group (n = 7), I/R group (n = 7), montelukast and I/R (MIR) group (n = 7), and Hypericum perforatum and I/R (HPIR) group (n = 7). After 60 min of ischemia through obstruction of the superior mesenteric artery, 24 h of reperfusion was maintained. Ten minutes prior to the reperfusion period, the MIR group received 7 mg/kg of intraperitoneal montelukast and the HPIR group received 7 mg/kg of intraperitoneal Hypericum perforatum. Malondialdehyde, glutathione, myeloperoxidase, and cardiotrophin-1 levels were measured from blood samples. A semiquantitative histological evaluation was performed. Results: Montelukast and Hypericum perforatum significantly reduced malondialdehyde levels and increased glutathione levels compared to the I/R group (P < 0.008). A statistically significant difference was also found between the I/R group and MIR and HPIR groups in terms of myeloperoxidase levels (P < 0.008). The MIR and HPIR groups showed increased cardiotrophin-1 levels compared to the control and I/R groups (P < 0.008 for all). The MIR and HPIR groups showed significantly lower histological scores compared to the I/R group (P = 0.03 and P = 0.007, respectively). Conclusion: This study demonstrated the preventive effects of montelukast and Hypericum perforatum on I/R-induced intestinal injuryen_US
dc.identifier.endpage386en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue3en_US
dc.identifier.pmid25558637en_US
dc.identifier.scopus2-s2.0-84897828629en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage381en_US
dc.identifier.trdizinid213076en_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TWpFek1EYzJOZz09
dc.identifier.urihttps://hdl.handle.net/20.500.12491/3104
dc.identifier.urihttps://doi.org/10.3906/sag-1303-101
dc.identifier.volume44en_US
dc.identifier.wosWOS:000334063700006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorOcak, Tarık
dc.institutionauthorDuran, Arif
dc.institutionauthorÖzyalvaçlı, Gülzade
dc.institutionauthorOcak, Zeynep
dc.institutionauthorTerzi, Elçin Hakan
dc.institutionauthorTosun, Mehmet
dc.institutionauthorErdem, Kemalettin
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMontelukasten_US
dc.subjectHypericum Perforatum
dc.subjectIntestinal Ischemia-Reperfusion Injury
dc.titleProtective effects of montelukast and Hypericum perforatum against intestinal ischemia-reperfusion injury in hamstersen_US
dc.typeArticleen_US

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