The resistance to major antituberculous drugs of mycobacterium tuberculosis strains isolated from the respiratory system specimens of tuberculosis patients in Duzce, Turkey

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dc.authorid0000-0001-6203-5039
dc.authorid0000-0002-4330-2864
dc.authorid0000-0002-7413-1367
dc.authorid0000-0001-8224-8242
dc.authorid0000-0002-6154-7961
dc.contributor.authorÖztürk, C. Elif
dc.contributor.authorBalbay, Öner A.
dc.contributor.authorKaya, Demet
dc.contributor.authorCeyhan, İsmail
dc.contributor.authorBulut, İsmet
dc.contributor.authorŞahin, İdris
dc.date.accessioned2021-06-23T19:18:35Z
dc.date.available2021-06-23T19:18:35Z
dc.date.issued2005
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractThough generally curable, tuberculosis (TB) is becoming increasingly resistant to commonly used antibiotics. Drug-resistant and multidrug-resistant (MDR)-TB is a consequence of monotherapy, insufficient drug therapy and national TB control programs. The present study was designed to reveal the resistance to major antimicrobial drugs (isoniazid [INH], streptomycin [SM], ethambutol [EMB], and rifampicin [RIF]) of Mycobacterium tuberculosis isolated from the respiratory specimens of TB patients in Duzce, Turkey. A total of 62 TB patients (46 male, 16 female; age: 17-75 mean: 42 +/- 15.9) were included in the study; 52 (83.8%) were new cases and susceptible to all anti-TB drugs, while 10 (16.2%) were previously treated cases. Antimicrobial susceptibility tests were performed by the proportion method in Lowenstein-Jensen medium. Fifty-two of the 62 (83.8%) isolated M. tuberculosis strains were found to be susceptible to all drugs, and 7 (11.3%), 5 (8%), and 3 (4.8%) were resistant to SM, INH, and RIF, respectively; 3 (4.8%) were MDR. There were no EMB-resistant strains. The results of this study. show the presence of drug-resistant and MDR strains of TB at Duzce in the northwest part of Turkey.en_US
dc.identifier.endpage49en_US
dc.identifier.issn1344-6304
dc.identifier.issn1884-2836
dc.identifier.issue1en_US
dc.identifier.pmid15728994en_US
dc.identifier.scopus2-s2.0-15844364014en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage47en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5763
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-15844364014&partnerID=40&md5=197812e4955c322aecf09c163e517126
dc.identifier.volume58en_US
dc.identifier.wosWOS:000227398900014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖztürk, C. Elif
dc.institutionauthorBalbay, Öner A.
dc.institutionauthorKaya, Demet
dc.institutionauthorBulut, İsmet
dc.institutionauthorŞahin, İdris
dc.language.isoenen_US
dc.publisherNatl Inst Infectious Diseasesen_US
dc.relation.ispartofJapanese Journal Of Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMajor Antituberculousen_US
dc.subjectMycobacterium
dc.subjectTuberculosis
dc.subjectRespiratory Specimens
dc.titleThe resistance to major antituberculous drugs of mycobacterium tuberculosis strains isolated from the respiratory system specimens of tuberculosis patients in Duzce, Turkeyen_US
dc.typeArticleen_US

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