The effect of erythropoietin to pulmonary injury and mast cells secondary to acute pancreatitis

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dc.authorid0000-0001-8990-5073
dc.authorid0000-0002-4600-1290
dc.authorid0000-0002-8317-7092
dc.contributor.authorKorkmaz, Taner
dc.contributor.authorKahramansoy, Nurettin
dc.contributor.authorKılıçgün, Ali
dc.contributor.authorFırat, Tülin
dc.date.accessioned2021-06-23T18:55:12Z
dc.date.available2021-06-23T18:55:12Z
dc.date.issued2014
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractBackground: Acute pancreatitis is a life-threatening necroinflammatory disease that is characterized by systemic inflammatory response syndrome and acute lung injury even in its very first days. Erythropoietin (EPO) is a hormone considered as an antiapoptotic and cytoprotective with observed receptors of anti-inflammatory effect on organs apart from the liver and the kidneys. In this study, the effects of EPO on pulmonary mast cells and on secondary injury caused by acute pancreatitis are investigated. Methods. Twenty one Wistar Albino rats were divided into three groups - sham, control, and EPO groups - with 7 rats per group. Pancreatitis was induced by administering 4.5% sodium taurocholate into the pancreatic duct. A 1000 U/kg/day dosage (three times) of EPO was administered to the EPO group. Blood urea nitrogen (BUN), creatinine, amylase, and troponin I in the serum were studied; and lung, kidney, brain, and heart tissues were examined histopathologically. Results: There were no histopathological changes in the other organ tissues except for the lung tissue. Compared to the control group, the EPO group showed significantly reduced alveolar hemorrhage, septal neutrophil infiltration, lung wall thickness score, and mast cell count in the lung tissue. Conclusions: Administration of EPO reduces the mast cell count and lung wall thickness, and it reduces the alveolar hemorrhage and septal infiltration induced by acute pancreatitis.en_US
dc.identifier.doi10.1186/1756-0500-7-267
dc.identifier.issn1756-0500
dc.identifier.issue1en_US
dc.identifier.pmid24761770en_US
dc.identifier.scopus2-s2.0-84899927971en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1186/1756-0500-7-267
dc.identifier.urihttps://hdl.handle.net/20.500.12491/4709
dc.identifier.volume7en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKorkmaz, Taner
dc.institutionauthorKahramansoy, Nurettin
dc.institutionauthorKılıçgün, Ali
dc.institutionauthorFırat, Tülin
dc.language.isoenen_US
dc.publisherBioMed Central Ltd.en_US
dc.relation.ispartofBMC Research Notesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute Lung Injuryen_US
dc.subjectAcute Pancreatitisen_US
dc.subjectErythropoietinen_US
dc.subjectMast cellen_US
dc.titleThe effect of erythropoietin to pulmonary injury and mast cells secondary to acute pancreatitisen_US
dc.typeArticleen_US

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