The role of oxidative stress in chemotherapy-induced gonadotoxicity in a rat model, and the protective effects of Nigella Sativa oil on oxidative stress, the anti-Mullerian hormone level, and apoptosis

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dc.authorid0000-0001-9307-5674en_US
dc.authorid0000-0003-0434-3206en_US
dc.authorid0000-0002-2705-4522en_US
dc.contributor.authorÇetinkaya, K.
dc.contributor.authorAtasever, Melahat
dc.contributor.authorErişgin, Züleyha
dc.contributor.authorSönmez, Çiğdem
dc.contributor.authorAlışık, Murat
dc.contributor.authorÖzer, Çiğdem
dc.date.accessioned2024-05-24T11:21:26Z
dc.date.available2024-05-24T11:21:26Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionThis study was supported by Scientific Research Project, Giresun University, Turkey (Project grant number: SAG-BAP-A-140316-95).en_US
dc.description.abstractOBJECTIVE: This study aimed to determine the role of oxidative stress (OS) in carboplatin-induced gonadotoxicity and whether Nigella Sativa oil (NSO), an herbal antioxidant, has a protective effect on ovarian apoptosis, OS, and the anti-Mullerian hormone (AMH) level in a rat model. MATERIALS AND METHODS: The study included 24 adult female rats that were divided into 4 treatment groups. Group A saline + saline (sham group); group B: NSO + saline; group C: saline + carboplatin; group D: NSO + carboplatin. Saline, NSO, and carboplatin were administered intraperitoneally 24 and/or 48 h before sacrification as 4 mL/kg, 4 mL/kg, and 80 mg/kg, respectively. Apoptosis, OS parameters, and AMH were measured. RESULTS: Oxidant levels and apoptosis were higher, whereas AMH and the antioxidants were lower in group C than in group A. Apoptosis, OS parameters, and AMH levels were negatively affected by chemotherapy (CTx) in group C whilst improvement in those parameters was observed in group D following NSO pretreatment. The levels of apoptosis and malondialdehyde (MDA), an OS parameter, in group D were lower than in group C as they declined from 34.3% to 8.65% (p = 0.002) and from 199.4 nmol/g tissue to 136.4 nmol/g tissue (p = 0.002), respectively. However, the slight increase in AMH level from 2.7 ng/mL to 3.5 ng/mL due to the NSO effect was not significant between groups C and D. CONCLUSIONS: The present findings show that carboplatin has adverse effects on AMH, ovarian tissue apoptosis, and OS parameters. NSO pretreatment might protect ovarian tissue and decrease CTx-induced ovarian injury by decreasing OS and apoptosis, but the protective effect of NSO on AMH is limited.en_US
dc.description.sponsorshipScientific Research Project, Giresun University, Turkey; [SAG-BAP-A-140316-95]en_US
dc.identifier.citationCetinkaya, K., Atasever, M., Erisgin, Z., Sonmez, C., Ozer, C., Coskun, B., & Alisik, M. (2023). The role of oxidative stress in chemotherapyinduced gonadotoxicity in a rat model, and the protective effects of Nigella Sativa oil on oxidative stress, the anti-Müllerian hormone level, and apoptosis. European Review for Medical & Pharmacological Sciences, 27(13).en_US
dc.identifier.endpage6350en_US
dc.identifier.issn1128-3602
dc.identifier.issue13en_US
dc.identifier.pmid#YOKen_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage6343en_US
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:001045159300009
dc.identifier.uriPUBMED ID: 37458651
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12162
dc.identifier.volume27en_US
dc.identifier.wosWOS:001045159300009en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorAlışık, Murat
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review for Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidanten_US
dc.subjectApoptosisen_US
dc.subjectGonadotoxicityen_US
dc.subjectNigella Sativa Oilen_US
dc.subjectOxidative Stressen_US
dc.subjectOvarian Reserveen_US
dc.titleThe role of oxidative stress in chemotherapy-induced gonadotoxicity in a rat model, and the protective effects of Nigella Sativa oil on oxidative stress, the anti-Mullerian hormone level, and apoptosisen_US
dc.typeArticleen_US

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