Effects of omentin on flap viability: An experimental research on rats

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dc.authorid0000-0002-3060-6420en_US
dc.authorid0000-0001-9077-2976
dc.authorid0000-0002-8317-7092
dc.authorid0000-0002-5502-7046
dc.contributor.authorEfeoğlu, Fatih Burak
dc.contributor.authorGökkaya, Ali
dc.contributor.authorKarabekmez, Furkan Erol
dc.contributor.authorFırat, Tülin
dc.contributor.authorGörgü, Metin
dc.date.accessioned2021-06-23T19:51:18Z
dc.date.available2021-06-23T19:51:18Z
dc.date.issued2019
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Viability decreases at the distal parts with an increase in the length of flaps. In this study, we evaluated the effects of subcutaneously administered omentin on flap viability, where it is applied to distal one-third part of McFarlane flaps elevated from the rat's dorsal skin. Materials and methods: Twenty-four adult, female, Sprague-Dawley rats were used. Subjects were divided into three groups; group 1 is the control group, group 2 received omentin 1 week before flap elevation, and group 3 received omentin 2 d before and at the day of flap elevation. About 1 cc (300 nanogram/cc) omentin applied by subcutaneous injections to the distal one-third flap. Photos are taken daily for macroscopic evaluations. The 3-mm full thickness punch biopsies at the third day and 1-cm(2) biopsies at the seventh day from the middle of the one-third distal third of the flaps were taken. Necrotic and viable areas were measured. Neutrophil counting, epidermis thickness, inflammation, edema, and vascular endothelial growth factor (VEGF) immune staining were evaluated using histopathological analyses. Endothelial Nitric Oxide Synthase (eNOS) expression was performed by ELISA. Results: Omentin increased the percentage of the viable areas of flaps, epidermal thickness, number of newly formed blood vessels, and eNOS expression levels. The results showed statistical significance. Conclusions: Omentin human increases the viable areas of flaps and may be used for enhancement of flap survival.en_US
dc.identifier.doi10.1080/2000656X.2019.1632206
dc.identifier.endpage355en_US
dc.identifier.issn2000-656X
dc.identifier.issn2000-6764
dc.identifier.issue6en_US
dc.identifier.pmid31244355en_US
dc.identifier.scopus2-s2.0-85068110652en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage347en_US
dc.identifier.urihttps://doi.org/10.1080/2000656X.2019.1632206
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9962
dc.identifier.volume53en_US
dc.identifier.wosWOS:000478355100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorEfeoğlu, Fatih Burak
dc.institutionauthorGökkaya, Ali
dc.institutionauthorFırat, Tülin
dc.institutionauthorGörgü, Metin
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal Of Plastic Surgery And Hand Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFlap Survivalen_US
dc.subjectOmentinen_US
dc.subjectEndothelial Nitric Oxide Synthaseen_US
dc.titleEffects of omentin on flap viability: An experimental research on ratsen_US
dc.typeArticleen_US

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