The effects of leptin administration to amygdala region on anxiety, depression and learning behaviors: change in seretonine and glutamate levels

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dc.authorid0000-0002-0000-3768en_US
dc.authorid0000-0001-5245-6294
dc.authorid0000-0002-5509-8717
dc.authorid0000-0002-6793-6888
dc.contributor.authorOrallar, Hayriye
dc.contributor.authorKarakaş, Fatma Pehlivan
dc.contributor.authorBozat, Bihter Gökçe
dc.contributor.authorCoşkun, Hamit
dc.date.accessioned2021-06-23T19:43:05Z
dc.date.available2021-06-23T19:43:05Z
dc.date.issued2016
dc.departmentBAİBÜ, Fen Edebiyat Fakültesi, Psikoloji Bölümüen_US
dc.departmentBAİBÜ, Fen Edebiyat Fakültesi, Biyoloji Bölümü
dc.departmentBAİBÜ, Ziraat Fakültesi, Kanatlı Hayvan Yetiştiriciliği Bölümü
dc.departmentBAİBÜ, Ziraat Fakültesi, Tarla Bitkileri Bölümü
dc.description.abstractAIM: Leptin is a hormone secreted by adipose tissue and involved in modulation of food intake. In addition to these functions, it plays a role in various physiological events such as anxiety, depression and learning. The aim of this study was the investigation of effects of leptin administration to amygdala on anxiety, depression and learning behaviors. In addition, changing of serotonin and glutamate neurotransmitter levels interaction between behavior. METHODS: Presentstudy used Wistar albino rats. Animals were separated 3 groupssuch aslow dose (0.1µg/kg) and high dose (1µg/kg) leptin and saline (control) intraamigdalar administration group. In thisstudy, we planned two procedures. Firstly, a special cannula was implanted into amygdala region of rats and leptin and saline were injected in thisregion by infusion pump. After leptin injections, behavioral tests were performed. In the second study, the extracellular fluid was collected by microdialysis from the amygdale region.The levels of serotonin and glutamate were measured by HPLC. RESULTS: The first experiment demonstrated that in the open field, low dose leptin administrated rats spent more time at the center (F(2,57)= 3.97 p=0.02), showed more zone transition than control ones (F(2,57)= 3.22 p=0.04). In the elevated plus maze, high and low doses leptin administrated rats spent more time in the open arms(F(2,55)= 6.77 p=0.002) and also high dose leptin injected rats showed more frequency of entering open arms (F(2,55)= 9.97 p=0.001). In Porsolt test, low dose leptin administrated ratsshowed high mobility in center than sham group (F(2,55)= 4.30 p=0.02). In the Morris water maze, low dose leptin administrated rats spent more time over the platform (F(2,45)= 3.50 p=0.04). The second experiment demonstrated that serotonin and glutamate levels increased in the first hour after the leptin injections (p<0.05). CONCLUSIONS: Present study suggests that both high and low leptin administration to rat brain playsa role as anxiolytic and antidepression agents in ratsen_US
dc.identifier.endpage74en_US
dc.identifier.issn1748-1708
dc.identifier.issn1748-1716
dc.identifier.startpage74en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8687
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000383578300195
dc.identifier.volume218en_US
dc.identifier.wosWOS:000383578300195en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorCoşkun, Hamit
dc.institutionauthorOrallar, Hayriye
dc.institutionauthorKarakaş, Fatma Pehlivan
dc.institutionauthorBozat, Bihter Gökçe
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofActa Physiologicaen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnxiety, Depression and Learning Behaviorsen_US
dc.subjectSeretonine and Glutamate Levels
dc.subjectAmygdala Region
dc.subjectLeptin
dc.titleThe effects of leptin administration to amygdala region on anxiety, depression and learning behaviors: change in seretonine and glutamate levelsen_US
dc.typeConference Objecten_US

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WoS İndeksli Yayınlar Koleksiyonu
Biyoloji Bölümü Koleksiyonu
Kanatlı Hayvan Yetiştiriciliği Bölümü Koleksiyonu
Psikoloji Bölümü Koleksiyonu
Tarla Bitkileri Bölümü Koleksiyonu