Effect of montelukast on acute lung injury induced by intestinal ischemia and reperfusion in rats

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dc.authorid0000-0002-2119-9448en_US
dc.authorid0000-0001-5387-2628
dc.authorid0000-0002-4552-0048
dc.authorid0000-0002-8317-7092
dc.authorid0000-0003-4721-8616
dc.contributor.authorTerzi, Elçin Hakan
dc.contributor.authorDuran, Arif
dc.contributor.authorFırat, Tülin
dc.contributor.authorOcak, Tarık
dc.contributor.authorKükner, Aysel
dc.date.accessioned2021-06-23T19:36:49Z
dc.date.available2021-06-23T19:36:49Z
dc.date.issued2014
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractAims: Lungs are the most affected remote organs after intestinal ischemia/reperfusion. The aim of our study is to investigate the effects of montelukast on intestinal ischemia/reperfusion-induced acute pulmonary injury, mast cells, and apoptosis. Materials and methods': Wistar Albino rats were used in the study. Control, intestinal ischemia/reperfusion (IIR), and IRR+montelukast groups, each comprising six rats, were constructed. Ischemia was induced by ligating the superior mesenteric artery for 60 min, followed by 60 min of reperfusion. Montelukast at a dose of 7 mg/kg was administered intraperitoneally 10 min before reperfusion. Lung tissues were fixed in neutral formalin. Paraffin sections were stained with hematoxylin-eosin and toluidine blue to assess mast cells. Pulmonary damage was graded, and mast cells were counted. Apoptotic cells were examined by terminal deoxynucleotidyl transferase dUTP nick-end labelling (TUNEL) staining. Results: Thickening of the inter-alveolar wall, capillary congestion, haemorrhage, edema, and accumulation of numerous inflammatory cells around the vessels were observed in the lung specimens of the IIR group. Wall thickness, edema, haemorrhage, and inflammatory cell infiltration were less severe in the montelukast-treated group. The number of mast cells and apoptotic cells with positive TUNEL staining was found to be increased in the IRR group and decreased in the montelukast-treated group. Conclusion: Montelukast alleviated tissue damage and reduced the number of mast cells and apoptotic epithelial cells caused by IIR-induced acute pulmonary injury. These results suggest a new approach for the prevention or treatment of secondary lung injury.en_US
dc.identifier.endpage417en_US
dc.identifier.issn0393-6384
dc.identifier.issn2283-9720
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84898464618en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage411en_US
dc.identifier.urihttps://www.actamedicamediterranea.com/archive/2014/medica-2/effect-of-montelukast-on-acute-lung-injury-induced-by-intestinal-ischemia-and-reperfusion-in-rats/document
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8060
dc.identifier.volume30en_US
dc.identifier.wosWOS:000335937900019en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorTerzi, Elçin Hakan
dc.institutionauthorDuran, Arif
dc.institutionauthorFırat, Tülin
dc.institutionauthorOcak, Tarık
dc.institutionauthorKükner, Aysel
dc.language.isoenen_US
dc.publisherCarbone Editoreen_US
dc.relation.ispartofActa Medica Mediterraneaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIntestinal Ischemia/Reperfusionen_US
dc.subjectLungen_US
dc.subjectMontelukasten_US
dc.subjectApoptosisen_US
dc.subjectMast Cellsen_US
dc.titleEffect of montelukast on acute lung injury induced by intestinal ischemia and reperfusion in ratsen_US
dc.typeArticleen_US

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