Oxidative stress and lipid peroxidation products: effect of pinealectomy or exogenous melatonin injections on biomarkers of tissue damage during acute pancreatitis

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dc.authorid0000-0002-4060-3354en_US
dc.authorid0000-0001-8540-1935
dc.contributor.authorÇöl, Cavit
dc.contributor.authorDinler, Kahraman
dc.contributor.authorHasdemir, Oğuz
dc.contributor.authorBüyükaşık, Oktay
dc.contributor.authorBuğdaycı, Güler
dc.date.accessioned2021-06-23T19:27:12Z
dc.date.available2021-06-23T19:27:12Z
dc.date.issued2010
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBACKGROUND: Melatonin (N-acetyl-5-methoxytripta-mine) is a free radical scavenger and a strong antioxidant, secreted by the pineal gland. In this study, we evaluated the effects of decreasing and increasing serum melatonin levels on malonyldialdehyde (MDA), superoxide dismutase (SOD), and reduced glutathione (GSH) levels in pancreatic tissue from rats with experimental acute pancreatitis. METHODS: Experimental acute pancreatitis was induced in three groups of Wistar albino rats (10 animals per group) by pancreatic ductal ligation. The first group had only acute pancreatitis and served as the control. Surgical pinealectomy was added to acute pancreatitis in the second group, removing the source of endogenous melatonin (low melatonin levels group). The third group was given 0.1 ml daily intraperitoneal injections of 20 mg/ml melatonin solution for one week (high melatonin levels group). The effects of melatonin levels were evaluated by comparison of the levels of MDA, SOD, and GS in pancreatic tissue. RESULT: We found that intraperitoneal melatonin injections decreased the levels of MDA and increased the levels of SOD and GSH in pancreatic tissue. CONCLUSION: Exogenous melatonin has a preventive effect on lipid peroxidation and oxidative damage in acute pancreatitis.en_US
dc.identifier.endpage82en_US
dc.identifier.issn1499-3872
dc.identifier.issn2352-9377
dc.identifier.issue1en_US
dc.identifier.pmid20133234en_US
dc.identifier.scopus2-s2.0-77149131799en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage78en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6759
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/20133234/
dc.identifier.volume9en_US
dc.identifier.wosWOS:000274505000013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÇöl, Cavit
dc.institutionauthorDinler, Kahraman
dc.institutionauthorHasdemir, Oğuz
dc.institutionauthorBüyükaşık, Oktay
dc.institutionauthorBuğdaycı, Güler
dc.language.isoenen_US
dc.publisherZhejiang Univ Sch Medicineen_US
dc.relation.ispartofHepatobiliary & Pancreatic Diseases Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPineal Glanden_US
dc.subjectAcute Pancreatitisen_US
dc.subjectMelatoninen_US
dc.subjectOxidative Damageen_US
dc.titleOxidative stress and lipid peroxidation products: effect of pinealectomy or exogenous melatonin injections on biomarkers of tissue damage during acute pancreatitisen_US
dc.typeArticleen_US

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