A chemically induced experimental colitis model with a simple combination of acetic acid and trinitrobenzene sulphonic acid

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dc.authorid0000-0002-7161-2907en_US
dc.authorid0000-0002-4060-3354en_US
dc.authorid0000-0002-3487-1264en_US
dc.authorid0000-0002-6553-4500en_US
dc.contributor.authorCinpolat, Havva Yasemin
dc.contributor.authorBuğdaycı, Güler
dc.contributor.authorŞengül, Neriman
dc.contributor.authorAstarcı, Hesna Müzeyyen
dc.date.accessioned2024-06-06T11:02:37Z
dc.date.available2024-06-06T11:02:37Z
dc.date.issued2023en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: It was aimed to induce a new experimental colitis model by using acetic acid and trinitrobenzene sulphonic acid together and to investigate the severity of inflammation biochemically and histopathologically in comparison with other models. Methods: Fifty-six Wistar albino male rats were randomly divided into 4 groups as control, acetic acid, trinitrobenzene sulphonic acid, and combined groups, and the animals were sacrificed following the induction of colitis on the third day and on the seventh day. The serum amyloid A and myeloperoxidase were tested in plasma samples, and the tumor necrosis factor-alpha, interleukin 33, and ST2 were assayed in colon tissue samples with enzyme-linked immunosorbent assay in addition to histopathological examination. Results: There were statistically significant differences between the combined and the control groups both on the third day and on the seventh day in all parameters. There was no difference between the acetic acid group on the seventh day and the control groups in biochemical parameters. Conclusions: The acetic acid model forms acute colitis. The combined model is found to be more successful in forming inflammation when compared to other models.en_US
dc.identifier.citationCinpolat, H. Y., Buğdaycı, G., Şengül, N., & Astarcı, H. M. (2023). A Chemically Induced Experimental Colitis Model with a Simple Combination of Acetic Acid and Trinitrobenzene Sulphonic Acid. The Turkish Journal of Gastroenterology, 34(3), 196.en_US
dc.identifier.doi10.5152/tjg.2022.22174
dc.identifier.endpage202en_US
dc.identifier.issn2148-5607
dc.identifier.issue3en_US
dc.identifier.pmid36511608en_US
dc.identifier.scopus2-s2.0-85150311254en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage196en_US
dc.identifier.trdizinid1169478en_US
dc.identifier.urihttp://dx.doi.org/10.5152/tjg.2022.22174
dc.identifier.urihttps://hdl.handle.net/20.500.12491/12205
dc.identifier.volume34en_US
dc.identifier.wosWOS:001043949300002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBuğdaycı, Güler
dc.institutionauthorŞengül, Neriman
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcetic Aciden_US
dc.subjectInflammatory Bowel Diseaseen_US
dc.subjectInterleukin 33en_US
dc.subjectST2en_US
dc.subjectTrinitrobenzene Sulphonic Aciden_US
dc.subjectUlcerative-Colitisen_US
dc.titleA chemically induced experimental colitis model with a simple combination of acetic acid and trinitrobenzene sulphonic aciden_US
dc.typeArticleen_US

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