Interaction between chlamydia pneumoniae seropositivity, inflammation and risk factors for atherosclerosis in patients with severe coronary stenosis

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dc.authorid0000-0002-1273-0604en_US
dc.authorid0000-0002-1964-424Xen_US
dc.authorid0000-0003-1937-9244
dc.contributor.authorYavuz, Mehmet Tevfik
dc.contributor.authorYavuz, Özlem
dc.contributor.authorYazıcı, Mehmet
dc.contributor.authorGüler, Selver
dc.contributor.authorÖzhan, Hakan
dc.contributor.authorAlbayrak, Sinan
dc.contributor.authorCoşkun, Abdurrahman
dc.date.accessioned2021-06-23T19:18:53Z
dc.date.available2021-06-23T19:18:53Z
dc.date.issued2006
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective. To investigate whether Chlamydia pneumoniae ( Cpn) seropositivity in patients with suspected coronary artery disease ( CAD) ( n = 81) is associated with increases in markers of inflammation, the severity of coronary atherosclerosis, and traditional risk factors for cardiovascular events. Material and methods. The severity of coronary atherosclerosis was ranked by Gensini score. Inflammation and endothelial dysfunction were evaluated using white blood cell counts and levels of high- sensitivity C- reactive protein ( hs- CRP), ferritin, tumour necrosis factor-alpha ( TNF-alpha), interleukins 1 beta and 6 ( IL- 1 beta, IL- 6), soluble intercellular adhesion molecule- 1 (sICAM-1), E-selectin and oxidized LDL ( oxLDL), and these were compared between Cpn- seropositive and seronegative individuals. Results. IgA and IgG Cpn seropositivity were significantly associated with the presence of CAD ( p = 0.005) and were independent predictive factors for the severity of coronary atherosclerosis ( p = 0.005). Elevated levels of IL- 6 ( p = 0.027) and triglyceride ( p50.038) and low levels of high- density lipoprotein cholesterol ( HDL- C) ( p = 0.038) were significantly predicted by Cpn IgA and IgG seropositivity. Conclusions. Seropositivity for Cpn is a risk factor for patients with significant angiographically documented coronary stenosis. Additionally, Cpn seropositivity was significantly associated with dyslipidemia and elevated IL-6, known risk factors for CAD. These observations indicate that Cpn infection may be one entry point to the causal or contributory pathways that lead to atherosclerosis and its clinical manifestations.en_US
dc.identifier.doi10.1080/00365510600931114
dc.identifier.endpage534en_US
dc.identifier.issn0036-5513
dc.identifier.issn1502-7686
dc.identifier.issue6en_US
dc.identifier.pmid17000560en_US
dc.identifier.scopus2-s2.0-33749022762en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage523en_US
dc.identifier.urihttps://doi.org/10.1080/00365510600931114
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5828
dc.identifier.volume66en_US
dc.identifier.wosWOS:000240743500008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYavuz, Mehmet Tevfik
dc.institutionauthorYavuz, Özlem
dc.institutionauthorYazıcı, Mehmet
dc.institutionauthorGüler, Selver
dc.institutionauthorÖzhan, Hakan
dc.institutionauthorAlbayrak, Sinan
dc.institutionauthorCoşkun, Abdurrahman
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofScandinavian Journal Of Clinical & Laboratory Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdhesion Moleculesen_US
dc.subjectCytokinesen_US
dc.subjectDyslipidemiaen_US
dc.subjectIL-6 Levelsen_US
dc.titleInteraction between chlamydia pneumoniae seropositivity, inflammation and risk factors for atherosclerosis in patients with severe coronary stenosisen_US
dc.typeArticleen_US

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