Is there a relationship between cord blood pregnancy-associated plasma protein-A and birth weight and length?

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dc.authorid0000-0001-9941-4999en_US
dc.authorid0000-0002-8467-0065en_US
dc.authorid0000-0002-5352-775X
dc.authorid0000-0003-0032-9589
dc.contributor.authorŞenses, Dursun Ali
dc.contributor.authorCoşkun, Abdurrahman
dc.contributor.authorKiseli, Mine
dc.contributor.authorBerberoğlu, Murat
dc.contributor.authorKandemir, Ömer
dc.contributor.authorDuran, Sadık
dc.date.accessioned2021-06-23T19:20:06Z
dc.date.available2021-06-23T19:20:06Z
dc.date.issued2007
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Infants whose mothers had low serum pregnancy-associated plasma protein-A (PAPP-A) in the first trimester were observed to have intrauterine growth retardation. Aim: Suggesting that PAPP-A plays an important role in the availability and activity of insulin-like growth factors (IGFs), which affect growth, we aimed to investigate cord blood PAPP-A levels of infants with different birth lengths and weights. Study design and outcome measures: The study included 97 full-term, live-birth neonates. After birth, their lengths and weights were measured. Cord blood PAPP-A Levels were measured with an ultra sensitive enzyme-linked immunosorbent assay (ELISA). Results: There was a significant negative correlation between cord blood PAPP-A levels and birth weight (r=-0.23; P=0.023) and length (r=-0.24; P=0.016). Using the classification made according to their length, it was found that newborns with short Lengths had significantly higher mean PAPP-A levels than neonates with normal and tong lengths (P=0.022; P=0.002, respectively), whereas the difference between infants with normal lengths and infants with Long lengths was not found to be statistically significant (P > 0.05). On the other hand, there was a difference between the mean PAPP-A levels of the neonate groups classified according to weight; however, these differences were not statistically significant (P > 0.05). Conclusion: We concluded that increased cord blood PAPP-A levels were associated with birth length and weight decreases; however, PAPP-A levels affected birth length more than birth weight. (c) 2006 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.earlhumdev.2006.10.005
dc.identifier.endpage482en_US
dc.identifier.issn0378-3782
dc.identifier.issue7en_US
dc.identifier.pmid17161560en_US
dc.identifier.scopus2-s2.0-34249315464en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage479en_US
dc.identifier.urihttps://doi.org/10.1016/j.earlhumdev.2006.10.005
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6058
dc.identifier.volume83en_US
dc.identifier.wosWOS:000247539100011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorŞenses, Dursun Ali
dc.institutionauthorCoşkun, Abdurrahman
dc.institutionauthorDuran, Sadık
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofEarly Human Developmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGrowthen_US
dc.subjectIGFen_US
dc.subjectIGFBP-4en_US
dc.subjectIUGRen_US
dc.subjectNewbornen_US
dc.subjectPAPP-Aen_US
dc.titleIs there a relationship between cord blood pregnancy-associated plasma protein-A and birth weight and length?en_US
dc.typeArticleen_US

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