Cochlear involvement in Familial Mediterranean Fever : a new feature of an old disease

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dc.authorid0000-0002-2408-5294en_US
dc.authorid0000-0003-1685-0352en_US
dc.authorid0000-0002-4646-7250
dc.contributor.authorKöybaşı, Serap
dc.contributor.authorAtasoy, Halil İbrahim
dc.contributor.authorBiçer, Yusuf Özgür
dc.contributor.authorTuğ, Esra
dc.date.accessioned2021-06-23T19:33:54Z
dc.date.available2021-06-23T19:33:54Z
dc.date.issued2012
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjectives: In this study we first aimed to assess the cochlear functions in children with Familial Mediterranean Fever. The second aim was to investigate the correlation between the hearing levels and some clinical features of Familial Mediterranean Fever including the duration of the disease, age at onset, genetic analysis and colchicine use. Methods: Thirty-four children with Familial Mediterranean Fever and 27 age matched children were included in the study. Following otologic examination, all children underwent audiometric evaluation, including Pure Tone Average measurements and Distortion Product Otoaoustic Emission testing. Audiological results of the two groups were compared and correlation between the audiologic status and clinical parameters of the disease like the duration of disease, age at onset, mutations and colchicine treatment were studied. Results: Pure tone audiometry hearing levels were within normal levels in both groups. Hearing thresholds of Familial Mediterranean Fever patients were found to be increased at frequencies 8000, 10,000, 12,500 and 16,000 (p<0.05). In otoacoustic emission evaluation, distortion products and signal-noise ratio of FMF children were lower in the tested frequencies, from 1400 Hz to 4000 Hz (p<0.05). Interaction of the disease duration and age of disease onset was found to predict hearing levels, distortion products and signal-noise ratios of children with Familial Mediterranean Fever (F value = 2.034; p = 0.033). Conclusions: To our knowledge this is the first study demonstrating cochlear involvement in children with Familial Mediterranean Fever which showed increased hearing thresholds at higher frequencies in audiometry together with decreased distortion products and signal-noise ratios demonstrated by distortion product otoacoustic emission testing. Similar studies must be carried out on adult patients to see if a clinical hearing impairment develops. The possible mechanisms that cause cochlear involvement and the effect of colchicine treatment on cochlear functions must be enlightened. (C) 2011 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijporl.2011.11.013
dc.identifier.endpage247en_US
dc.identifier.issn0165-5876
dc.identifier.issn1872-8464
dc.identifier.issue2en_US
dc.identifier.pmid22177320en_US
dc.identifier.scopus2-s2.0-84855952639en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage244en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijporl.2011.11.013
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7273
dc.identifier.volume76en_US
dc.identifier.wosWOS:000300135800015en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKöybaşı, Serap
dc.institutionauthorAtasoy, Halil İbrahim
dc.institutionauthorBiçer, Yusuf Özgür
dc.institutionauthorTuğ, Esra
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofInternational Journal Of Pediatric Otorhinolaryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFamilial Mediterranean Feveren_US
dc.subjectAudiometryen_US
dc.subjectOtoacoustic Emissionsen_US
dc.subjectHearing Lossen_US
dc.titleCochlear involvement in Familial Mediterranean Fever : a new feature of an old diseaseen_US
dc.typeArticleen_US

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