How do thiol disulfide balance and copper-ceruloplasmin levels change in women using copper intrauterine devices?

dc.authorid0000-0002-9097-1024en_US
dc.authorid0000-0003-0434-3206en_US
dc.authorid0000-0001-8895-6864en_US
dc.authorid0000-0001-5191-1072en_US
dc.authorid0000-0002-2996-3236en_US
dc.contributor.authorKorkmaz, Hilal
dc.contributor.authorDeveci, Canan Dura
dc.contributor.authorAlışık, Murat
dc.contributor.authorKorkmaz, Vakkas
dc.contributor.authorKurdoğlu, Zehra
dc.contributor.authorErel, Özcan
dc.date.accessioned2023-09-04T08:03:06Z
dc.date.available2023-09-04T08:03:06Z
dc.date.issued2022en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractObjectives We aimed to examine the change in plasma copper (Cu) level and copper transport proteins level before inserting Cu-IUD and after one menstrual cycle and to show the effect of this change on the thiol disulfide balance in women using copper-containing intrauterine device (Cu-IUD). Method Thirty-three reproductive women who admitted to the gynecology clinic and inserted Cu-IUD were examined in this study. Thiol-disulfide homeostasis, plasma Cu and ceruloplasmin levels and ceruloplasmin ferroxidase activity were measured using the blood samples collected just before inserting Cu-IUD and after one menstrual cycle. Results Plasma copper level (p = 0.006), ceruloplasmin (p < 0.001), Ceruloplasmin Ferroxidase (p = 0.005), thiol disulfide homeostasis parameters; native thiol (NT) (p = 0.004), and total thiol (p = 0.003) levels increased significantly. Conclusion After one menstrual cycle in women inserted intrauterine Cu-IUD for contraception, plasma levels of Cu, which is the oxidant molecule, increased significantly. Both plasma ceruloplasmin level and ceruloplasmin ferroxidase activity increased due to elevated Cu levels. This increased oxidant status in the acute period was balanced by the increase in the native thiol level.en_US
dc.identifier.citationKorkmaz, H., Deveci, C. D., Alışık, M., Korkmaz, V., Kurdoğlu, Z., Erel, Ö., & Üstün, Y. (2022). How do thiol disulfide balance and copper-ceruloplasmin levels change in women using copper intrauterine devices?. Gynecological Endocrinology, 38(8), 689-692.en_US
dc.identifier.doi10.1080/09513590.2022.2089650
dc.identifier.endpage692en_US
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.issue8en_US
dc.identifier.pmid35758879en_US
dc.identifier.scopus2-s2.0-85133086006en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage689en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11642
dc.identifier.volume38en_US
dc.identifier.wosWOS:000817266200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAlışık, Murat
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofGynecological Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCopperen_US
dc.subjectCeruloplasminen_US
dc.subjectCeruloplasmin Ferroxidase Activityen_US
dc.subjectThiol-Disulfide Homeostasisen_US
dc.subjectOxidative Stressen_US
dc.subjectHomeostasisen_US
dc.titleHow do thiol disulfide balance and copper-ceruloplasmin levels change in women using copper intrauterine devices?en_US
dc.typeArticleen_US

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