How do thiol disulfide balance and copper-ceruloplasmin levels change in women using copper intrauterine devices?
Yükleniyor...
Dosyalar
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objectives We aimed to examine the change in plasma copper (Cu) level and copper transport proteins level before inserting Cu-IUD and after one menstrual cycle and to show the effect of this change on the thiol disulfide balance in women using copper-containing intrauterine device (Cu-IUD). Method Thirty-three reproductive women who admitted to the gynecology clinic and inserted Cu-IUD were examined in this study. Thiol-disulfide homeostasis, plasma Cu and ceruloplasmin levels and ceruloplasmin ferroxidase activity were measured using the blood samples collected just before inserting Cu-IUD and after one menstrual cycle. Results Plasma copper level (p = 0.006), ceruloplasmin (p < 0.001), Ceruloplasmin Ferroxidase (p = 0.005), thiol disulfide homeostasis parameters; native thiol (NT) (p = 0.004), and total thiol (p = 0.003) levels increased significantly. Conclusion After one menstrual cycle in women inserted intrauterine Cu-IUD for contraception, plasma levels of Cu, which is the oxidant molecule, increased significantly. Both plasma ceruloplasmin level and ceruloplasmin ferroxidase activity increased due to elevated Cu levels. This increased oxidant status in the acute period was balanced by the increase in the native thiol level.
Açıklama
Anahtar Kelimeler
Copper, Ceruloplasmin, Ceruloplasmin Ferroxidase Activity, Thiol-Disulfide Homeostasis, Oxidative Stress, Homeostasis
Kaynak
Gynecological Endocrinology
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
38
Sayı
8
Künye
Korkmaz, H., Deveci, C. D., Alışık, M., Korkmaz, V., Kurdoğlu, Z., Erel, Ö., & Üstün, Y. (2022). How do thiol disulfide balance and copper-ceruloplasmin levels change in women using copper intrauterine devices?. Gynecological Endocrinology, 38(8), 689-692.
