The effects of lycium barbarum l. polysaccharides on learning behaviors of young ovariectomized female rats

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dc.authorid0000-0002-0000-3768en_US
dc.authorid0000-0001-5245-6294
dc.authorid0000-0002-5509-8717
dc.authorid0000-0002-6793-6888
dc.contributor.authorBozat, Bihter Gökçe
dc.contributor.authorKarakaş, Fatma Pehlivan
dc.contributor.authorOrallar, Hayriye
dc.contributor.authorCoşkun, Hamit
dc.date.accessioned2021-06-23T19:43:05Z
dc.date.available2021-06-23T19:43:05Z
dc.date.issued2016
dc.departmentBAİBÜ, Ziraat Fakültesi, Tarla Bitkileri Bölümüen_US
dc.departmentBAİBÜ, Ziraat Fakültesi, Kanatlı Hayvan Yetiştiriciliği Bölümü
dc.departmentBAİBÜ, Fen Edebiyat Fakültesi, Psikoloji Bölümü
dc.departmentBAİBÜ, Fen Edebiyat Fakültesi, Biyoloji Bölümü
dc.description.abstractAIM: Lycium barbarum Linnaeus is also known as goji berry, wolfberry or super fruit. The red-orange and sweet fruits of goji berryhave been used in herbal medicine and health food for the thousand years. L. barbarum fruits have polysaccharides which have many beneficial effects for human such as ocular neuroprotective, antioxidant, immunomodulator, hepatic pretection and antitumor effects. In the present study, the aim was to investigate the effects of the L. barbarum polysaccharides (LBP) on learning behavior in ovariectomized young female rats(two months age) using the Morris water maze test. METHODS: Two weeks after ovariectomy applications, rats were divided into five groups: control (distile water 3 mL/kg, gavage, per day), low dose LBP (20 mg/kg, 3 mL/kg, gavage, per day), high dose LBP (200 mg/kg, 3 mL/kg, gavage, per day), estrogen (1 mg/kg, 3 mL/kg, gavage, per day) and donepezil (1 mg/kg, 3 mL/kg, gavage, per day) and two subgroup within the each group: sham (pseudo ovariectomized rat) and overiectomized groups. After all treatments were applied for thirty consecutive days, behavioral test was applied. Blood serum samples of all rats were collected and levels of antioxidant enzymes (SOD, CAT, GPX, MDA and E2) of the samples were detected by ELISA method. All animals weights were measured weekly. RESULTS: The findings of the present experiment demonstrated that platform finding time and travelled distance of the LBP administred ovariectomized groups were less than estrogen and donepezil administred groups. CONCLUSIONS: In conclusion, LBP enhances the learning performance and antioxidant enzyme activity of ovariectomized female rats.en_US
dc.identifier.endpage75en_US
dc.identifier.issn1748-1708
dc.identifier.issn1748-1716
dc.identifier.startpage74en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8686
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000383578300196
dc.identifier.volume218en_US
dc.identifier.wosWOS:000383578300196en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.institutionauthorKarakaş, Fatma Pehlivan
dc.institutionauthorBozat, Bihter Gökçe
dc.institutionauthorOrallar, Hayriye
dc.institutionauthorCoşkun, Hamit
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofActa Physiologicaen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFemale Ratsen_US
dc.subjectLycium barbarum L. Polysaccharides
dc.subjectYoung Ovariectomized Female Rats
dc.titleThe effects of lycium barbarum l. polysaccharides on learning behaviors of young ovariectomized female ratsen_US
dc.typeConference Objecten_US

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