The effects of lycium barbarum l. polysaccharides on learning behaviors of young ovariectomized female rats
Küçük Resim Yok
Dosyalar
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley-Blackwell
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
AIM: Lycium barbarum Linnaeus is also known as goji berry, wolfberry or super fruit. The red-orange and sweet fruits of goji berryhave been used in herbal medicine and health food for the thousand years. L. barbarum fruits have polysaccharides which have many beneficial effects for human such as ocular neuroprotective, antioxidant, immunomodulator, hepatic pretection and antitumor effects. In the present study, the aim was to investigate the effects of the L. barbarum polysaccharides (LBP) on learning behavior in ovariectomized young female rats(two months age) using the Morris water maze test. METHODS: Two weeks after ovariectomy applications, rats were divided into five groups: control (distile water 3 mL/kg, gavage, per day), low dose LBP (20 mg/kg, 3 mL/kg, gavage, per day), high dose LBP (200 mg/kg, 3 mL/kg, gavage, per day), estrogen (1 mg/kg, 3 mL/kg, gavage, per day) and donepezil (1 mg/kg, 3 mL/kg, gavage, per day) and two subgroup within the each group: sham (pseudo ovariectomized rat) and overiectomized groups. After all treatments were applied for thirty consecutive days, behavioral test was applied. Blood serum samples of all rats were collected and levels of antioxidant enzymes (SOD, CAT, GPX, MDA and E2) of the samples were detected by ELISA method. All animals weights were measured weekly. RESULTS: The findings of the present experiment demonstrated that platform finding time and travelled distance of the LBP administred ovariectomized groups were less than estrogen and donepezil administred groups. CONCLUSIONS: In conclusion, LBP enhances the learning performance and antioxidant enzyme activity of ovariectomized female rats.
Açıklama
Anahtar Kelimeler
Female Rats, Lycium barbarum L. Polysaccharides, Young Ovariectomized Female Rats
Kaynak
Acta Physiologica
WoS Q Değeri
Q1
Scopus Q Değeri
Cilt
218
