Effects of the inflammatory response on serum omentin levels in early acute and chronic pancreatitis

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dc.authorid0000-0002-7475-7298
dc.authorid0000-0001-7306-5233
dc.authorid0000-0003-4318-9619
dc.authorid0000-0002-3156-1076
dc.authorid0000-0002-4552-0048
dc.contributor.authorŞit, Mustafa
dc.contributor.authorAktaş, Gülali
dc.contributor.authorYılmaz, Edip Erdal
dc.contributor.authorAlçelik, Aytekin
dc.contributor.authorTerzi, Elçin Hakan
dc.contributor.authorTosun, Mehmet
dc.date.accessioned2021-06-23T18:55:22Z
dc.date.available2021-06-23T18:55:22Z
dc.date.issued2014
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground and Aims: Acute pancreatitis is an acute inflammation of the parenchyma of the pancreas. Several adipokines have been investigated in acute pancreatitis, and these cytokines contribute to inflammation in acute pancreatitis. However, not enough data exist regarding omentin in injuries of the pancreas. Because of a possible common pathogenesis, we aimed to study the association between pancreatic damage and serum omentin levels. Materials and Methods: Twenty-four Sprague Dowley rats weighing 200-250 g were randomly placed into three groups: a sham group (n=8), an acute pancreatitis group (n=8), and a chronic pancreatitis group (n=8). Both rats in the sham group underwent laparotomy, and 0.1 cc of saline solution was injected through the pancreatic canal. On the seventh day, a blood sample was obtained by abdominal aorta puncture, and the pancreas was resected for histological examination. In the acute and chronic pancreatitis groups, 0.1 cc of 4.5% Sodium Taurocholote was injected through the pancreatic canal. Blood samples were obtained and pancreatic resection was performed after 24 hours for the acute pancreatitis group and after 7 days for the chronic pancreatitis group. Results: Serum omentin levels of rats with chronic pancreatitis (49.37±2.82 ng/ml) were increased compared to both acute pancreatitis (37.79±1.24 ng/ml) (p<0.01) and sham rats (22.49±1.4 ng/ml) (p<0.01). In addition, the omentin level of rats with acute pancreatitis was significantly increased compared to the sham group (p<0.01). Conclusion: The elevation in omentin levels in rats in the early stage of pancreatitis was due to the anti-inflammatory effects of omentin; hence, elevated omentin levels improved insulin resistance and caused a significant reduction in glucose levels.en_US
dc.identifier.doi10.7471/CT.2014.1699
dc.identifier.endpagee152en_US
dc.identifier.issn0009-9074
dc.identifier.issue2en_US
dc.identifier.pmid24770824en_US
dc.identifier.scopus2-s2.0-84899738239en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpagee148en_US
dc.identifier.urihttps://doi.org/10.7471/CT.2014.1699
dc.identifier.urihttps://hdl.handle.net/20.500.12491/4754
dc.identifier.volume165en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorŞit, Mustafa
dc.institutionauthorAktaş, Gülali
dc.institutionauthorYılmaz, Edip Erdal
dc.institutionauthorAlçelik, Aytekin
dc.institutionauthorTerzi, Elçin Hakan
dc.institutionauthorTosun, Mehmet
dc.language.isoenen_US
dc.publisherSocieta Editrice Universoen_US
dc.relation.ispartofClinica Terapeuticaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute Pancreatitisen_US
dc.subjectChronic Pancreatitisen_US
dc.subjectOmentinen_US
dc.titleEffects of the inflammatory response on serum omentin levels in early acute and chronic pancreatitisen_US
dc.typeArticleen_US

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