Elucidating the potential side effects of current anti-seizure drugs for epilepsy

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dc.authorid0000-0002-3942-2097en_US
dc.authorid0000-0003-3477-3290en_US
dc.authorid0000-0003-0993-5622en_US
dc.contributor.authorAkyüz, Enes
dc.contributor.authorKöklü, Betül
dc.contributor.authorÖzenen, Cansu
dc.contributor.authorArulsamy, Alina
dc.date.accessioned2023-07-13T07:44:46Z
dc.date.available2023-07-13T07:44:46Z
dc.date.issued2021en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractOver the decades, various interventions have been developed and utilized to treat epilepsy. However, the majority of epileptic patients are often first prescribed anti-epileptic drugs (AED), now known as anti-seizure drugs (ASD), as the first line of defense to suppress their seizures and regain their quality of life. ASDs exert their anti-convulsant effects through various mechanisms of action, including regulation of ion channels, blocking glutamate-mediated stimulating neurotransmitter interaction, and enhancing the inhibitory GABA transmission. About one-third of epileptic patients are often resistant to anti-convulsant drugs, while others develop numerous side effects, which may lead to treatment discontinuation and further deterioration of quality of life. Common side effects of ASDs include headache, nausea and dizziness. However, more adverse effects, such as auditory and visual problems, skin problems, liver dysfunction, pancreatitis and kidney disorders may also be witnessed. Some ASDs may even result in life-threatening conditions as well as serious abnormalities, especially in patients with comorbidities and in pregnant women. Nevertheless, some clinicians had observed a reduction in the development of side effects post individualized ASD treatment. This suggests that a careful and well-informed ASD recommendation to patients may be crucial for an effective and side-effect-free control of their seizures. Therefore, this review aimed to elucidate the anticonvulsant effects of ASDs as well as their side effect profile by discussing their mechanism of action and reported adverse effects based on clinical and preclinical studies, thereby providing clinicians with a greater understanding of the safety of current ASDs.en_US
dc.identifier.citationAkyüz, E., Köklü, B., Ozenen, C., Arulsamy, A., & Shaikh, M. F. (2021). Elucidating the potential side effects of current anti-seizure drugs for epilepsy. Current neuropharmacology, 19(11), 1865.en_US
dc.identifier.doi10.2174/1570159X19666210826125341
dc.identifier.endpage1883en_US
dc.identifier.issn1570-159X
dc.identifier.issn1875-6190
dc.identifier.issue11en_US
dc.identifier.pmid34525933en_US
dc.identifier.scopus2-s2.0-85122166715en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1865en_US
dc.identifier.urihttp://dx.doi.org/10.2174/1570159X19666210826125341
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11278
dc.identifier.volume19en_US
dc.identifier.wosWOS:000720321300007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖzenen, Cansu
dc.language.isoenen_US
dc.publisherBentham Science Publisheren_US
dc.relation.ispartofCurrent Neuropharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - İdari Personel ve Öğrencien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAEDen_US
dc.subjectASDen_US
dc.subjectPharmacological Treatmenten_US
dc.subjectAdverse Event Profileen_US
dc.subjectAntiepileptic Drugsen_US
dc.subjectValproic Aciden_US
dc.titleElucidating the potential side effects of current anti-seizure drugs for epilepsyen_US
dc.typeArticleen_US

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