Effects of probiotic bacteria on central neuronal activation in experimental colitis

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dc.authorid0000-0002-3487-1264en_US
dc.authorid0000-0001-5912-9392en_US
dc.authorid0000-0002-3535-6977en_US
dc.authorid0000-0002-0595-7237en_US
dc.authorid0000-0002-8647-1545en_US
dc.authorid0000-0002-8317-7092en_US
dc.contributor.authorŞengül, Neriman
dc.contributor.authorTöre, Fatma
dc.contributor.authorIşık, Sevil
dc.contributor.authorAslım, Belma
dc.contributor.authorUçar, Gülberk
dc.contributor.authorFırat, Tülin
dc.date.accessioned2023-10-31T05:59:16Z
dc.date.available2023-10-31T05:59:16Z
dc.date.issued2022en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Brain-gut axis dysregulation is observed in inflammatory bowel disease. However, the effect of altered gut flora on neuro-immunomodulation and its role in the pathogenesis of inflammatory bowel disease are unknown. The aims of this study are to determine (i) whether colitis modifies the expression of c-fos, a marker of general neuronal activation in the brain and (ii) whether this activation could be modulated by probiotic bacteria. Methods: In this study, 28 Sprague-Dawley rats were divided into 4 groups: colitis-probiotic group, non-colitis-fed-control group receiving probiotic Lactobacillus delbrueckii subsp. Bulgaricus B3 strain for 7 days, colitis group, and sham group receiving only sodium chloride. Colitis was induced by intracolonic administration of trinitrobenzene sulfonic acid-ethanol. The expression of c-fos was detected by immunohistochemistry in the brain tissue. Cytokines and inflammatory mediators were analyzed in the plasma. Histological scores and oxidative status were analyzed in the colon samples. Results: The inflammatory response was accompanied by increased levels of cytokines, lipid peroxidation activities, c-fos expression in the medial nucleus of the amygdala, and decreased levels of antioxidant enzymes in the colitis (P < .001). Probiotic treatment reversed those effects. Also, histopathologic scores were significantly lower in the probiotic-treated groups compared to the colitis group (P = .035). In contrast, the expression of c-fos was significantly increased in the paraventricular nucleus of hypothalamus in the probiotic-treated rats (P <.001). Conclusion: Colitis and intestinal inflammation are associated with the activation of neurons in the limbic system creating stress-like effects in the brain. Probiotics diversely modulate limbic response and hypothalamic axis activity in addition to protective effects in inflammation.en_US
dc.identifier.citationŞengül, N., Töre, F., Işık, S., Aslım, B., Uçar, G., Fırat, T., ... & Kükner, A. (2022). Effects of Probiotic Bacteria on Central Neuronal Activation in Experimental Colitis. The Turkish Journal of Gastroenterology, 33(4), 304.en_US
dc.identifier.doi10.5152/tjg.2022.201175
dc.identifier.endpage311en_US
dc.identifier.issn2148-5607
dc.identifier.issue4en_US
dc.identifier.pmid35550538en_US
dc.identifier.scopus2-s2.0-85130638627en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage304en_US
dc.identifier.trdizinid515960en_US
dc.identifier.uri10.5152/tjg.2022.201175
dc.identifier.urihttp://dx.doi.org/10.5152/tjg.2022.201175
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11799
dc.identifier.volume33en_US
dc.identifier.wosWOS:000800904200017en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorŞengül, Neriman
dc.institutionauthorFırat, Tülin
dc.language.isoenen_US
dc.publisherAVESen_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectC-Fosen_US
dc.subjectGut-Brain Axisen_US
dc.subjectMicrobiotaen_US
dc.subjectLactobacillusen_US
dc.subjectProbioticen_US
dc.titleEffects of probiotic bacteria on central neuronal activation in experimental colitisen_US
dc.typeArticleen_US

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