The effect of diosmin hesperidin on intestinal ischaemia - reperfusion injury

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dc.authorid0000-0002-5916-2675en_US
dc.authorid0000-0002-9041-341Xen_US
dc.authorid0000-0002-0317-7181
dc.authorid0000-0001-5807-6698
dc.contributor.authorPehlivan, Mevlüt
dc.contributor.authorHazinedaroğlu, Selçuk Mevlüt
dc.contributor.authorKayaoğlu, Hüseyin Ayhan
dc.contributor.authorErkek, Ayhan Bülent
dc.contributor.authorKeklik, T.
dc.contributor.authorCanbolat, Orhan
dc.contributor.authorKoçak, Suzan
dc.date.accessioned2021-06-23T19:17:45Z
dc.date.available2021-06-23T19:17:45Z
dc.date.issued2004
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractAim : The effect of Diosmin Hesperidin on intestinal ischaemia reperfusion injury was evaluated in an experimental model in rats. Material and methods: Forty Spraque-Dawley rats were divided into 4 groups of (n = 10) (sham, sham + Diosmin Hesperidin, Reperfusion, Reperfusion + Diosmin Hesperidin). Diosmin Hesperidin oral gavage was administrated at a dose of 50 mg/kg to rats 14 and 2 hours before the operation and 30 minutes of ischaemia and 30 minutes of reperfusion was performed in the groups when appropriate. Ileum samples were resected for histopathological evaluation and tissue malondialdehyde (MDA) and myeloperoxidase (MPA) level determination. Results : Mean mucosal injury score of IR group (4,50 0,23) was significantly higher than the other groups (p < 0.05). Although mean mucosal injury score of IR + DH group was higher than sham and sham + DH groups, difference was not statistically significant (p > 0.05). Tissue MDA and MPO activities of IR group were 45,55 +/- 2.61 nmol/g/wet tissue and 1.68 +/- 0.25 U/g/wet tissue respectively and were significantly higher than the other groups (p < 0.008). Although tissue MDA and MPO activities of IR + DH group was higher than sham and sham + DH groups, differences were not statistically significant (p > 0.008). Conclusion : Diosmin Hesperidin seems to be effective in the prevention of intestinal reperfusion injury.en_US
dc.identifier.doi10.1080/00015458.2004.11679649
dc.identifier.endpage718en_US
dc.identifier.issn0001-5458
dc.identifier.issue6en_US
dc.identifier.pmid15663281en_US
dc.identifier.scopus2-s2.0-12244259096en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage715en_US
dc.identifier.urihttps://doi.org/10.1080/00015458.2004.11679649
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5534
dc.identifier.volume104en_US
dc.identifier.wosWOS:000226165500023en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorPehlivan, Mevlüt
dc.institutionauthorHazinedaroğlu, Selçuk Mevlüt
dc.language.isoenen_US
dc.publisherActa Medical Belgicaen_US
dc.relation.ispartofActa Chirurgica Belgicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIschaemiaen_US
dc.subjectReperfusion Injuryen_US
dc.subjectDiosmin Hesperidinen_US
dc.titleThe effect of diosmin hesperidin on intestinal ischaemia - reperfusion injuryen_US
dc.typeArticleen_US

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