The effect of diosmin hesperidin on intestinal ischaemia - reperfusion injury
Yükleniyor...
Dosyalar
Tarih
2004
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Acta Medical Belgica
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aim : The effect of Diosmin Hesperidin on intestinal ischaemia reperfusion injury was evaluated in an experimental model in rats. Material and methods: Forty Spraque-Dawley rats were divided into 4 groups of (n = 10) (sham, sham + Diosmin Hesperidin, Reperfusion, Reperfusion + Diosmin Hesperidin). Diosmin Hesperidin oral gavage was administrated at a dose of 50 mg/kg to rats 14 and 2 hours before the operation and 30 minutes of ischaemia and 30 minutes of reperfusion was performed in the groups when appropriate. Ileum samples were resected for histopathological evaluation and tissue malondialdehyde (MDA) and myeloperoxidase (MPA) level determination. Results : Mean mucosal injury score of IR group (4,50 0,23) was significantly higher than the other groups (p < 0.05). Although mean mucosal injury score of IR + DH group was higher than sham and sham + DH groups, difference was not statistically significant (p > 0.05). Tissue MDA and MPO activities of IR group were 45,55 +/- 2.61 nmol/g/wet tissue and 1.68 +/- 0.25 U/g/wet tissue respectively and were significantly higher than the other groups (p < 0.008). Although tissue MDA and MPO activities of IR + DH group was higher than sham and sham + DH groups, differences were not statistically significant (p > 0.008). Conclusion : Diosmin Hesperidin seems to be effective in the prevention of intestinal reperfusion injury.
Açıklama
Anahtar Kelimeler
Ischaemia, Reperfusion Injury, Diosmin Hesperidin
Kaynak
Acta Chirurgica Belgica
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
104
Sayı
6
