Non-invasive fibrosis tests are correlated with necroinflammatory actvity of liver in patients with chronic hepatitis B

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dc.authorid0000-0002-2572-0376
dc.authorid0000-0001-8590-4831
dc.authorid0000-0003-3726-5945
dc.authorid0000-0001-9919-6055
dc.contributor.authorÖzyalvaçlı, Gülzade
dc.contributor.authorKüçükbayrak, Abdülkadir
dc.contributor.authorKurt, Mevlüt
dc.contributor.authorGürel, Kamil
dc.contributor.authorGüneş, Öznur
dc.contributor.authorÜstün, Cemal
dc.contributor.authorAkdeniz, Hayrettin
dc.date.accessioned2021-06-23T18:55:21Z
dc.date.available2021-06-23T18:55:21Z
dc.date.issued2014
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground. The gold standarda method used for assessing necroinflammatory activity and fibrosis in the liver is a liver biopsy which has many disadvantages. Therefore, many investigators have been trying to develop non-invasive tests for predicting liver fibrosis score (LFS) of these patients. The aim of this study is to describe the relationship between certain non-invasive fibrosis markers with LFS and histological activity index (HAI) detected histopathologically by liver biopsy in chronic hepatitis B patients. Materials and Methods. A total of 54 patients who had undergone a liver biopsy with the diagnosis of chronic HBV infection were included in the study. Ishak scoring was used for the evaluation of liver fibrosis, and a modified Knodell HAI was used for demonstration of necroinflammation. In this study, non-invasive fibrosis tests were calculated as described in previous studies. Results. Histological acitivity index was positively correlated with age, age/platelet index, cirrhosis discriminant score (CDS), AST/ platelet ratio index (APRI), AST/platelet/GGT/AFP index (APGA), fibro-quotient (Fibro-Q), Goteburg University Cirrhosis Index (Guci), and Platelet/Age/Phosphatase/AFP/AST index (PAPAS). When divided into two groups according to HAI, Guci and APGA were found significantly different both in >4 and >4 HAI groups than the other group. In ROC analysis performed for LFS; PAPAS, APGA, FFI and APRI were the markers having the highest AUC levels, and in ROC analysis performed for HAI; Guci, APRI and APGA were the markers with the highest AUC levels. Conclusion: APRI, APGA and GUCI tests may be helpful in prediction of necroinflammatory scores in the liver.en_US
dc.identifier.doi10.7417/CT.2014.1719
dc.identifier.endpage204en_US
dc.identifier.issn0009-9074
dc.identifier.issue3en_US
dc.identifier.pmid24999574en_US
dc.identifier.scopus2-s2.0-84903199918en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpagee199en_US
dc.identifier.urihttps://doi.org/10.7417/CT.2014.1719
dc.identifier.urihttps://hdl.handle.net/20.500.12491/4747
dc.identifier.volume165en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖzyalvaçlı, Gülzade
dc.institutionauthorKüçükbayrak, Abdülkadir
dc.institutionauthorKurt, Mevlüt
dc.institutionauthorGürel, Kamil
dc.institutionauthorGüneş, Öznur
dc.institutionauthorÜstün, Cemal
dc.institutionauthorAkdeniz, Hayrettin
dc.language.isoenen_US
dc.publisherSocieta Editrice Universoen_US
dc.relation.ispartofClinica Terapeuticaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiopsyen_US
dc.subjectFibrosisen_US
dc.subjectHepatitis Ben_US
dc.subjectInflammationen_US
dc.subjectLiveren_US
dc.titleNon-invasive fibrosis tests are correlated with necroinflammatory actvity of liver in patients with chronic hepatitis Ben_US
dc.typeArticleen_US

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