Non-invasive fibrosis tests are correlated with necroinflammatory actvity of liver in patients with chronic hepatitis B
Küçük Resim Yok
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Societa Editrice Universo
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background. The gold standarda method used for assessing necroinflammatory activity and fibrosis in the liver is a liver biopsy which has many disadvantages. Therefore, many investigators have been trying to develop non-invasive tests for predicting liver fibrosis score (LFS) of these patients. The aim of this study is to describe the relationship between certain non-invasive fibrosis markers with LFS and histological activity index (HAI) detected histopathologically by liver biopsy in chronic hepatitis B patients. Materials and Methods. A total of 54 patients who had undergone a liver biopsy with the diagnosis of chronic HBV infection were included in the study. Ishak scoring was used for the evaluation of liver fibrosis, and a modified Knodell HAI was used for demonstration of necroinflammation. In this study, non-invasive fibrosis tests were calculated as described in previous studies. Results. Histological acitivity index was positively correlated with age, age/platelet index, cirrhosis discriminant score (CDS), AST/ platelet ratio index (APRI), AST/platelet/GGT/AFP index (APGA), fibro-quotient (Fibro-Q), Goteburg University Cirrhosis Index (Guci), and Platelet/Age/Phosphatase/AFP/AST index (PAPAS). When divided into two groups according to HAI, Guci and APGA were found significantly different both in >4 and >4 HAI groups than the other group. In ROC analysis performed for LFS; PAPAS, APGA, FFI and APRI were the markers having the highest AUC levels, and in ROC analysis performed for HAI; Guci, APRI and APGA were the markers with the highest AUC levels. Conclusion: APRI, APGA and GUCI tests may be helpful in prediction of necroinflammatory scores in the liver.
Açıklama
Anahtar Kelimeler
Biopsy, Fibrosis, Hepatitis B, Inflammation, Liver
Kaynak
Clinica Terapeutica
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
165
Sayı
3
