Inhibitory effects of regorafenib, a multiple tyrosine kinase inhibitor, on corneal neovascularization

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dc.authorid0000-0003-1657-9099en_US
dc.authorid0000-0002-0893-4444en_US
dc.contributor.authorÖnder, Halil İbrahim
dc.contributor.authorErdurmuş, Mesut
dc.contributor.authorBucak, Yasin Yücel
dc.contributor.authorSimavlı, Hüseyin
dc.contributor.authorOktay, Murat
dc.contributor.authorKükner, Ahmet Şahap
dc.date.accessioned2021-06-23T19:36:03Z
dc.date.available2021-06-23T19:36:03Z
dc.date.issued2014
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractAIM: To evaluate the inhibitory effects of regorafenib (BAY 73 -4506), a multikinase inhibitor, on corneal neovascularization (NV). METHODS: Thirty adult male Sprague -Dawley rats weighing 250-300 g, were used. Corneal NV was induced by NaOH in the left eyes of each rat. Following the establishment of alkali burn, the animals were randomized into five groups according to topical treatment. Group 1 (n= 6) received 0.9% NaCl, Group 2 (n = 6) received dimethyl sulfoxide, Group 3 (n = 6) received regorafenib 1 mg/mL, Group 4 (n=6) received bevacizumab 5 mg/mL and Group 5 (n= 6) received 0.1% dexamethasone phosphate. On the 7d, the corneal surface covered with neovascular vessels was measured on photographs as the percentage of the cornea's total area using computer -imaging analysis. The corneas obtained from rats were semiquantitatively evaluated for caspase 3 and vascular endothelial growth factor by immunostaining. RESULTS: A statistically significant difference in the percent area of corneal NV was found among the groups (P <0.001). Although the Group 5 had the smallest percent area of corneal NV, there was no difference among Groups 3, 4 and 5 (P >0.005). There was a statistically significant difference among the groups in apoptotic cell density (P=0.002). The staining intensity of vascular endothelial growth factor in the epithelial and endothelial layers of cornea was significantly different among the groups (P<0.05). The staining intensity of epithelial and endothelial vascular endothelial growth factor was significantly weaker in Groups 3, 4 and 5 than in Groups 1 and 2. " CONCLUSION: Topical administration of regorafenib 1 mg/mL is partly effective for preventing alkali induced corneal NV in rats.en_US
dc.identifier.doi10.3980/j.issn.2222-3959.2014.02.06
dc.identifier.endpage225en_US
dc.identifier.issn2222-3959
dc.identifier.issn2227-4898
dc.identifier.issue2en_US
dc.identifier.pmid24790861en_US
dc.identifier.scopus2-s2.0-84899893095en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage220en_US
dc.identifier.urihttps://doi.org/10.3980/j.issn.2222-3959.2014.02.06
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7920
dc.identifier.volume7en_US
dc.identifier.wosWOS:000334656000006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKükner, Ahmet Şahap
dc.institutionauthorErdurmuş, Mesut
dc.language.isoenen_US
dc.publisherIjo Pressen_US
dc.relation.ispartofInternational Journal Of Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCorneal Neovascularizationen_US
dc.subjectRegorafeniben_US
dc.subjectTyrosine Kinase Inhibitoren_US
dc.titleInhibitory effects of regorafenib, a multiple tyrosine kinase inhibitor, on corneal neovascularizationen_US
dc.typeArticleen_US

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