Efficacy of antimicrobial photodynamic therapy administered using methylene blue, toluidine blue and tetra 2-mercaptopyridine substituted zinc phthalocyanine in root canals contaminated with Enterococcusaecalis

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dc.authorid0000-0001-9258-1866en_US
dc.authorid0000-0002-1773-9114
dc.contributor.authorKaraoğlu, Gamze Er
dc.contributor.authorAydın, Zeliha Uğur
dc.contributor.authorErdönmez, Demet
dc.contributor.authorGöl, Cem
dc.contributor.authorDurmuş, Mahmut
dc.date.accessioned2021-06-23T19:53:49Z
dc.date.available2021-06-23T19:53:49Z
dc.date.issued2020
dc.departmentBAİBÜ, Diş Hekimliği Fakültesi, Endodonti Ana Bilim Dalıen_US
dc.description.abstractBackground: Traditional chemomechanical treatment procedures are an indispensable part of endodontic treatment, however, additional treatment approaches such as antimicrobial photodynamic therapy (aPDT) may also be recommended for the elimination of residual microorganisms. In this study, the disinfection efficiency of aPDT performed using methylene blue (MB), toluidine blue (TB), and tetra 2-mercaptopyridine substituted zinc phthalocyanine (TM-ZnPc) was compared in the roots contaminated with Enterococcus faecalis (E. faecalis). Materials and methods: Forty-nine teeth with a single root and canal were included in this study. The roots were sterilized, and inoculated with E. faecalis. The roots were kept in an incubator for 30 days to form the biofilm. Forty-five teeth were prepared up to the F3 file of the ProTaperNext system under 2.5 % NaOCL irrigation. The samples were divided into three groups according to the type of used photosensitizer (PS) (n = 15); MB (313 mu M), TB (327 mu M), and TM-ZnPc (6 mu M). All PSs were irradiation with a light-emitting diode (LED) lamp (630 nm, 2-4 mW/cm(2)) for the 60 s. Two microbiological samples of the intracanal content were taken (one before and one immediately after additional aPDT in all groups) using sterile paper points. The colony-forming units per milliliter (CFU/mL) were calculated after 24 h of incubation at 37 degrees C. Results: After all aPDT protocols, intracanal bacterial load decreased significantly compared to the amount after chemomechanical preparation (P < 0.05). No significant difference in the reduction in intracanal bacterial load was found between the PSs (P < 0.05). Conclusions: In the current study, the aPDT protocol performed with TM-ZnPc provided similar antimicrobial efficacy, although it was used at a lower concentration compared to MB and TB. Therefore, the use of TM-ZnPc in intra-canal disinfection in endodontics seems promising.en_US
dc.identifier.doi10.1016/j.pdpdt.2020.102038
dc.identifier.issn1572-1000
dc.identifier.issn1873-1597
dc.identifier.pmid33010484en_US
dc.identifier.scopus2-s2.0-85093669987en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.pdpdt.2020.102038
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10272
dc.identifier.volume32en_US
dc.identifier.wosWOS:000600357900004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAydın, Zeliha Uğur
dc.institutionauthorGöl, Cem
dc.institutionauthorKaraoğlu, Gamze Er
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofPhotodiagnosis And Photodynamic Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntimicrobial Photodynamic Therapyen_US
dc.subjectEndodonticsen_US
dc.subjectEnterococcus Faecalisen_US
dc.subjectMethylene Blueen_US
dc.subjectToluidine Blueen_US
dc.subjectZinc Phthalocyanineen_US
dc.titleEfficacy of antimicrobial photodynamic therapy administered using methylene blue, toluidine blue and tetra 2-mercaptopyridine substituted zinc phthalocyanine in root canals contaminated with Enterococcusaecalisen_US
dc.typeArticleen_US

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