Evaluation of pregnancy-associated plasma protein-a levels in patients with chronic obstructive pulmonary disease and associations with disease severity

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dc.authorid0000-0002-4641-2866en_US
dc.authorid0000-0002-3156-1076en_US
dc.contributor.authorTalay, Fahrettin
dc.contributor.authorTosun, Mehmet
dc.contributor.authorYaşar, Zehra Asuk
dc.contributor.authorKurt, Özlem Kar
dc.contributor.authorKarği, Aysel
dc.contributor.authorÖztürk, Serkan
dc.contributor.authorÖzlü, Mehmet Fatih
dc.contributor.authorAlçelik, Aytekin
dc.date.accessioned2021-06-23T19:43:30Z
dc.date.available2021-06-23T19:43:30Z
dc.date.issued2016
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractChronic obstructive pulmonary disease (COPD) represents a systemic disorder characterized by chronic airflow limitation and an increased inflammatory response of the airways. Comorbidities are frequent in COPD and it is crucial to predict these in early stage for adequate management of COPD. Recent studies have reported that elevated levels of pregnancy-associated plasma protein-A (PAPP-A), a zinc-binding metalloproteinase, detected in patients with asthma, lung cancer, and pulmonary embolism and independently associated with cardiovascular events. We aimed to assess serum PAPP-A levels in COPD and the associations between disease severity. The study population consisted of 75 COPD patients and 35 healthy subjects as a control group. PAPP-A levels were measured by using ultrasensitive enzyme-linked immunosorbent assay. Elevated levels of PAPP-A were observed in patients with COPD on comparison with the controls (p = 0.000). The levels in stage 1 (34.73 +/- 22.97) and stage 2 (48.29 +/- 53.35) were significantly higher than stage 3 (20.58 +/- 22.98) and stage 4 (27.36 +/- 21.46) (p = 0.049). Increased PAPP-A levels may be a useful marker in management of COPD that seeks to prevent the development of comorbidities such as adverse cardiovascular diseases.en_US
dc.identifier.doi10.1007/s10753-016-0345-z
dc.identifier.endpage1133en_US
dc.identifier.issn0360-3997
dc.identifier.issn1573-2576
dc.identifier.issue3en_US
dc.identifier.pmid27090654en_US
dc.identifier.scopus2-s2.0-84964370142en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1130en_US
dc.identifier.urihttps://doi.org/10.1007/s10753-016-0345-z
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8792
dc.identifier.volume39en_US
dc.identifier.wosWOS:000376927500020en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTalay, Fahrettin
dc.institutionauthorTosun, Mehmet
dc.institutionauthorYaşar, Zehra Asuk
dc.institutionauthorKurt, Özlem Kar
dc.institutionauthorKarği, Aysel
dc.institutionauthorÖztürk, Serkan
dc.institutionauthorÖzlü, Mehmet Fatih
dc.institutionauthorAlçelik, Aytekin
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofInflammationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCOPDen_US
dc.subjectPAPP-Aen_US
dc.subjectDisease Severityen_US
dc.titleEvaluation of pregnancy-associated plasma protein-a levels in patients with chronic obstructive pulmonary disease and associations with disease severityen_US
dc.typeArticleen_US

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