Effect of heparin on inflammation : an animal model of tracheal stents

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dc.authorid0000-0003-1413-1266en_US
dc.contributor.authorBiçer, Yusuf Özgür
dc.contributor.authorKöybaşı, Serap
dc.contributor.authorSüslü, Ahmet E.
dc.contributor.authorKükner, Aysel
dc.contributor.authorTezcan, Erkan
dc.date.accessioned2021-06-23T19:35:35Z
dc.date.available2021-06-23T19:35:35Z
dc.date.issued2014
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractObjectives/Hypothesis: The objective of this study was to investigate the effect of systemic heparin on tracheal and wound healing. Study Design: An animal experiment using a tracheal stent model. Methods: Twenty Wistar albino rats were divided into two groups; a heparin group (n=10) that received 210 U/kg/d heparin sodium, and a saline group (n=10) that received 0.1 mL of 9% NaCl. Stents of 1 cm in length made of 8F feeding tube were placed into the tracheas of rats in both groups and stayed in place for 10 days. Ten days after removal of the stents, the rats were sacrificed and the tracheas were harvested. Histological evaluations of the tracheas were performed with respect to inflammatory parameters. Results: We observed significantly milder inflammation in the heparin group compared to the saline group in terms of inflammatory cell count, fibroblastic proliferation, edema, and vascularity at the site where the tracheal incision was made (P<.05). Inflammation tended to be of a lesser extent in the stent site in the heparin group (P>.05). Conclusions: We could demonstrate that heparin does inhibit fibroblast proliferation, inflammatory cell count, edema, and angiogenesis in this animal model. We believe that future studies can elucidate on laryngotracheal wound healing as well as their molecular mechanisms.en_US
dc.identifier.doi10.1002/lary.24684
dc.identifier.endpageE372en_US
dc.identifier.issn0023-852X
dc.identifier.issn1531-4995
dc.identifier.issue9en_US
dc.identifier.pmid24648297en_US
dc.identifier.scopus2-s2.0-84906689505en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpageE368en_US
dc.identifier.urihttps://doi.org/10.1002/lary.24684
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7824
dc.identifier.volume124en_US
dc.identifier.wosWOS:000341100500004en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorBiçer, Yusuf Özgür
dc.institutionauthorKöybaşı, Serap
dc.institutionauthorKükner, Aysel
dc.institutionauthorTezcan, Erkan
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofLaryngoscopeen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHeparinen_US
dc.subjectTracheaen_US
dc.subjectStenosisen_US
dc.titleEffect of heparin on inflammation : an animal model of tracheal stentsen_US
dc.typeArticleen_US

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