Acute toxoplasmosis and antioxidant levels in the liver, kidney and brain of rats

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dc.authorid0000-0001-8616-832X
dc.authorid265041
dc.authorid0000-0001-8741-5548
dc.authorid0000-0002-9026-4485
dc.authorid0000-0002-0000-3768
dc.contributor.authorTürkoğlu, Şule Aydın
dc.contributor.authorYaman, Kerem
dc.contributor.authorOrallar, Hayriye
dc.contributor.authorÇamsarı, Çağrı
dc.contributor.authorKarabörk, Şeyda
dc.contributor.authorAyaz, Erol
dc.date.accessioned2021-06-23T18:51:33Z
dc.date.available2021-06-23T18:51:33Z
dc.date.issued2018
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.departmentBAİBÜ, Ziraat Fakültesi, Kanatlı Hayvan Yetiştiriciliği Bölümü
dc.description.abstractToxoplasma gondii is a common protozoan parasite which causes toxoplasmosis worldwide. There are limited treatment options against T. gondii infection. Once transmitted, T. gondii can spread to many organs in the body, including the brain, liver and kidneys. One of the most common signs of toxoplasmosis is a rise in oxidative stress. Therefore, our aim was to determine the antioxidant levels in the brain, liver and kidney of rats infected with this parasite. In the present study, 2–4-months old Wistar albino rats were infected intraperitoneally with 1 x 104 mL of RH strain of T. gondii dispersed in 0.9% NaCl. Post-infection after 30 days, the experiment was terminated, the rats were sacrified, and the blood, brain, liver and kidney tissues were collected for analyses. Catalase (CAT), glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) levels were determined by ELISA assay. Increased SOD and GSH-Px levels were found in the liver of infected rats compared to controls; however, similar changes were not observed in other tested organs. These results suggest the increased oxidative stress caused by T. gondii infection can be efficiently alleviated, at least in the liver, by increased levels of antioxidant enzymes during post-infection. Further research will be required to determine the potential mechanisms of increasing antioxidant levels in the liver at 30 days post-infection, as well as the potential differences in antioxidant enzyme levels during the acute and chronic phases of toxoplasmosis.en_US
dc.description.urihttps://eds.p.ebscohost.com/eds/pdfviewer/pdfviewer?vid=2&sid=0574b336-9ca0-49ad-986f-339fe0b05473%40redis
dc.identifier.doi10.17420/ap6403.159
dc.identifier.endpage247en_US
dc.identifier.issn2299-0631
dc.identifier.issue3en_US
dc.identifier.pmid30316221en_US
dc.identifier.scopus2-s2.0-85054889315en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage241en_US
dc.identifier.urihttps://doi.org/10.17420/ap6403.159
dc.identifier.urihttps://hdl.handle.net/20.500.12491/3866
dc.identifier.volume64en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTürkoğlu, Şule Aydın
dc.institutionauthorYaman, Kerem
dc.institutionauthorOrallar, Hayriye
dc.institutionauthorÇamsarı, Çağrı
dc.institutionauthorKarabörk, Şeyda
dc.institutionauthorAyaz, Erol
dc.language.isoenen_US
dc.publisherNLM (Medline)en_US
dc.relation.ispartofAnnals of parasitologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectToxoplasma Gondiien_US
dc.subjectCAT
dc.subjectSOD
dc.subjectGSH-Px
dc.subjectAcute Infection
dc.titleAcute toxoplasmosis and antioxidant levels in the liver, kidney and brain of ratsen_US
dc.typeArticleen_US

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