Influence of selective dopamine agonist ropinirole on conditioned place preference and somatic signs of morphine withdrawal in rats

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dc.authorid0000-0003-1075-9574en_US
dc.authorid0000-0002-8468-394en_US
dc.contributor.authorShahzadi, Andlee
dc.contributor.authorYunusoğlu, Oruç
dc.contributor.authorKarabulut, Enes
dc.contributor.authorSönmez, Haktan
dc.contributor.authorYazıcı, Zeliha
dc.date.accessioned2023-08-02T13:35:54Z
dc.date.available2023-08-02T13:35:54Z
dc.date.issued2022en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractThe underlying mechanism of dependence and rewarding effects of morphine is imperative to understand. The primary aim of this study was to investigate whether ropinirole D2/3 agonist affects the rewarding and reinforcing properties of morphine-induced conditioned place preference (CPP) and withdrawal syndromes in rats. On day one, the animals were randomly divided to conduct the pre-test. The morphine (10 mg/kg, i.p.) and/or saline was administered on alternate days in an 8-day CPP session. On day 10, 15 min prior to the post-conditioning test (expression), a single dose of ropinirole (1, 2, and 5 mg/kg, i.p.) was given to rats. In extinction session, ropinirole was injected daily, and CPP was extinguished by repeated testing, with intervals of 3 days. Finally, reinstatement was assessed by administering ropinirole (1, 2, and 5 mg/kg) 15 min before the morphine injection. Morphine dependence was developed by administering increasing doses of morphine (10-50 mg/kg, i.p.). To assess withdrawal symptoms, ropinirole (1, 2, and 5 mg/kg) was injected 15 min before naloxone (2 mg/kg, s.c.) administration. The present study confirms that ropinirole attenuates expression and reinstatement of CPP, while it precipitates the extinction of morphine-induced CPP. Naloxone-precipitated morphine withdrawal symptoms, including wet dog shakes and weight loss, were attenuated although jumping was increased by a single ropinirole injection. Thus, ropinirole was influential in attenuating expression, reducing drug seeking and weakening reinstatement via the dopaminergic system. These findings show that ropinirole might affect neuro-adaptive changes related to dependence.en_US
dc.identifier.citationShahzadi, A., Yunusoglu, O., Karabulut, E., Sonmez, H., & Yazici, Z. (2022). Influence of selective dopamine agonist ropinirole on conditioned place preference and somatic signs of morphine withdrawal in rats. Frontiers in behavioral neuroscience, 16, 855241.en_US
dc.identifier.doi10.3389/fnbeh.2022.855241
dc.identifier.endpage10en_US
dc.identifier.issn1662-5153
dc.identifier.pmid35733518en_US
dc.identifier.scopus2-s2.0-85133369946en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttp://dx.doi.org/10.3389/fnbeh.2022.855241
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11421
dc.identifier.volume16en_US
dc.identifier.wosWOS:000813182500001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYunusoğlu, Oruç
dc.language.isoenen_US
dc.publisherFrontiers Media SAen_US
dc.relation.ispartofFrontiers in Behavioral Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMorphineen_US
dc.subjectConditioned Place Preferenceen_US
dc.subjectRopiniroleen_US
dc.subjectWithdrawal Syndromeen_US
dc.subjectExpressionen_US
dc.subjectReinstatementen_US
dc.titleInfluence of selective dopamine agonist ropinirole on conditioned place preference and somatic signs of morphine withdrawal in ratsen_US
dc.typeArticleen_US

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