Influence of selective dopamine agonist ropinirole on conditioned place preference and somatic signs of morphine withdrawal in rats
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Dosyalar
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Frontiers Media SA
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The underlying mechanism of dependence and rewarding effects of morphine is imperative to understand. The primary aim of this study was to investigate whether ropinirole D2/3 agonist affects the rewarding and reinforcing properties of morphine-induced conditioned place preference (CPP) and withdrawal syndromes in rats. On day one, the animals were randomly divided to conduct the pre-test. The morphine (10 mg/kg, i.p.) and/or saline was administered on alternate days in an 8-day CPP session. On day 10, 15 min prior to the post-conditioning test (expression), a single dose of ropinirole (1, 2, and 5 mg/kg, i.p.) was given to rats. In extinction session, ropinirole was injected daily, and CPP was extinguished by repeated testing, with intervals of 3 days. Finally, reinstatement was assessed by administering ropinirole (1, 2, and 5 mg/kg) 15 min before the morphine injection. Morphine dependence was developed by administering increasing doses of morphine (10-50 mg/kg, i.p.). To assess withdrawal symptoms, ropinirole (1, 2, and 5 mg/kg) was injected 15 min before naloxone (2 mg/kg, s.c.) administration. The present study confirms that ropinirole attenuates expression and reinstatement of CPP, while it precipitates the extinction of morphine-induced CPP. Naloxone-precipitated morphine withdrawal symptoms, including wet dog shakes and weight loss, were attenuated although jumping was increased by a single ropinirole injection. Thus, ropinirole was influential in attenuating expression, reducing drug seeking and weakening reinstatement via the dopaminergic system. These findings show that ropinirole might affect neuro-adaptive changes related to dependence.
Açıklama
Anahtar Kelimeler
Morphine, Conditioned Place Preference, Ropinirole, Withdrawal Syndrome, Expression, Reinstatement
Kaynak
Frontiers in Behavioral Neuroscience
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
16
Sayı
Künye
Shahzadi, A., Yunusoglu, O., Karabulut, E., Sonmez, H., & Yazici, Z. (2022). Influence of selective dopamine agonist ropinirole on conditioned place preference and somatic signs of morphine withdrawal in rats. Frontiers in behavioral neuroscience, 16, 855241.
