Long-term proton pump inhibitor use is a risk factor for mortality in patients hospitalized for COVID-19

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dc.authorid0000-0002-6054-9244en_US
dc.authorid0000-0002-4414-9929en_US
dc.authorid0000-0001-9532-8241en_US
dc.contributor.authorYozgat, Ahmet
dc.contributor.authorKasapoğlu, Benan
dc.contributor.authorCan, Güray
dc.contributor.authorTanoğlu, Alpaslan
dc.contributor.authorSakin, Yusuf Serdar
dc.contributor.authorYalçın, Kadir Serkan
dc.contributor.authorGürler, Müjgan
dc.date.accessioned2023-07-14T08:18:20Z
dc.date.available2023-07-14T08:18:20Z
dc.date.issued2021en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground and aim: The aim of this study is to evaluate whether the long-term (≥4 weeks) use of proton pump inhibitors (PPIs) is a risk factor for intubation requirement and mortality in patients hospitalized for COVID-19. Materials and methods: In this multicentric retrospective study, a total of 382 adult patients (≥18 years of age) with confirmed COVID-19 who were hospitalized for treatment were enrolled. The patients were divided into two groups according to the periods during which they used PPIs: the first group included patients who were not on PPI treatment, and the second group included those who have used PPIs for more than 4 weeks. Results: The study participants were grouped according to their PPI usage history over the last 6 months. In total, 291 patients did not use any type of PPI over the last 6 months, and 91 patients used PPIs for more than 4 weeks. Older age (HR: 1.047, 95% CI: 1.026–1.068), current smoking (HR: 2.590, 95% CI: 1.334–5.025), and PPI therapy for more than 4 weeks (HR: 1.83, 95% CI: 1.06–2.41) were found to be independent risk factors for mortality. Conclusion: The results obtained in this study show that using PPIs for more than 4 weeks is associated with negative outcomes for patients with COVID-19. Patients receiving PPI therapy should be evaluated more carefully if they are hospitalized for COVID-19 treatment.en_US
dc.identifier.citationYOZGAT, AHMET; KASAPOĞLU, BENAN; CAN, GÜRAY; TANOĞLU, ALPASLAN; SAKİN, YUSUF SERDAR; YALÇIN, KADİR SERKAN; GÜRLER, MÜJGAN; KAPLAN, MUSTAFA; KABAN, MEHMET GÖKTÜRK; KIRSOY, MEHMET; KARA, UMUT; and KEKİLLİ, MURAT (2021) "Long-term proton pump inhibitor use is a risk factor for mortality in patientshospitalized for COVID-19," Turkish Journal of Medical Sciences: Vol. 51: No. 4, Article 10. https://doi.org/10.3906/sag-2103-80 Available at: https://journals.tubitak.gov.tr/medical/vol51/iss4/10en_US
dc.identifier.doi10.3906/sag-2103-80
dc.identifier.endpage1681en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue4en_US
dc.identifier.pmid34110723en_US
dc.identifier.scopus2-s2.0-85114232754en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1675en_US
dc.identifier.trdizinid479976en_US
dc.identifier.urihttp://dx.doi.org/10.3906/sag-2103-80
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11286
dc.identifier.volume51en_US
dc.identifier.wosWOS:000691544700010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorCan, Güray
dc.institutionauthorGürler, Müjgan
dc.language.isoenen_US
dc.publisherScientific Technical Research Council Turkey-TÜBİTAKen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCovid-19en_US
dc.subjectProton Pump Inhibitorsen_US
dc.subjectMortalityen_US
dc.titleLong-term proton pump inhibitor use is a risk factor for mortality in patients hospitalized for COVID-19en_US
dc.typeArticleen_US

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