Long-term proton pump inhibitor use is a risk factor for mortality in patients hospitalized for COVID-19
Yükleniyor...
Dosyalar
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Scientific Technical Research Council Turkey-TÜBİTAK
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background and aim: The aim of this study is to evaluate whether the long-term (≥4 weeks) use of proton pump inhibitors (PPIs) is a
risk factor for intubation requirement and mortality in patients hospitalized for COVID-19.
Materials and methods: In this multicentric retrospective study, a total of 382 adult patients (≥18 years of age) with confirmed
COVID-19 who were hospitalized for treatment were enrolled. The patients were divided into two groups according to the periods
during which they used PPIs: the first group included patients who were not on PPI treatment, and the second group included those
who have used PPIs for more than 4 weeks.
Results: The study participants were grouped according to their PPI usage history over the last 6 months. In total, 291 patients did not
use any type of PPI over the last 6 months, and 91 patients used PPIs for more than 4 weeks. Older age (HR: 1.047, 95% CI: 1.026–1.068),
current smoking (HR: 2.590, 95% CI: 1.334–5.025), and PPI therapy for more than 4 weeks (HR: 1.83, 95% CI: 1.06–2.41) were found
to be independent risk factors for mortality.
Conclusion: The results obtained in this study show that using PPIs for more than 4 weeks is associated with negative outcomes for
patients with COVID-19. Patients receiving PPI therapy should be evaluated more carefully if they are hospitalized for COVID-19
treatment.
Açıklama
Anahtar Kelimeler
Covid-19, Proton Pump Inhibitors, Mortality
Kaynak
Turkish Journal of Medical Sciences
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
51
Sayı
4
Künye
YOZGAT, AHMET; KASAPOĞLU, BENAN; CAN, GÜRAY; TANOĞLU, ALPASLAN; SAKİN, YUSUF SERDAR; YALÇIN, KADİR SERKAN; GÜRLER, MÜJGAN; KAPLAN, MUSTAFA; KABAN, MEHMET GÖKTÜRK; KIRSOY, MEHMET; KARA, UMUT; and KEKİLLİ, MURAT (2021) "Long-term proton pump inhibitor use is a risk factor for mortality in patientshospitalized for COVID-19," Turkish Journal of Medical Sciences: Vol. 51: No. 4, Article 10. https://doi.org/10.3906/sag-2103-80
Available at: https://journals.tubitak.gov.tr/medical/vol51/iss4/10
