Effect of pregnancy on vocal cord histology: an animal experiment

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dc.authorid0000-0003-1413-1266en_US
dc.authorid0000-0002-4646-7250
dc.contributor.authorŞanal, Serap Köybaşı
dc.contributor.authorBiçer, Yusuf Özgür
dc.contributor.authorKükner, Aysel
dc.contributor.authorTezcan, Erkan
dc.date.accessioned2021-06-23T19:43:22Z
dc.date.available2021-06-23T19:43:22Z
dc.date.issued2016
dc.departmentBAİBÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractBackground: Voice may be affected during the period of pregnancy, especially in the third trimester. However, the exact mechanisms leading to the phonatory changes have not yet uncovered. Aims: The aim of this study is to investigate the possible histological changes in the vocal cords of the pregnant rats in three separate trimesters. Study Design: Animal experiment. Methods: Twenty-five Wistar-Albino female rats were divided into four groups: control group, pregnancy day 7 (Group 1), pregnancy day 14 (Group 2) and pregnancy day 20 (Group 3). The laryngeal specimens were obtained under general anesthesia. Histological assessment was performed using Hematoxylin-eosin and toluidine blue. A stereological analysis of vocal cord tissue was performed using a NIS-Elements D32 Imaging Software. Results: Lamina propria was observed to be edematous, and the lamina propria area was thickened starting from the second trimester. Glycosaminoglycans were observed to increase in the second trimester. Although none was encountered in the control, mast cells were observed in the lamina propria layer of the vocal cord starting in the muscular layer in the first trimester proceed to the subepithelial region as degranulated just before term. The covering epithelium remained unchanged throughout pregnancy. Conclusion: Lamina propria thickening may be attributed to both edema and increased glycosaminoglycans. The presence of mast cells in the cordal tissue may induce edema during pregnancy in rats.en_US
dc.identifier.doi10.5152/balkanmedj.2016.15286
dc.identifier.endpage452en_US
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue4en_US
dc.identifier.pmid27606142en_US
dc.identifier.scopus2-s2.0-84979937159en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage448en_US
dc.identifier.trdizinid201256en_US
dc.identifier.urihttps://doi.org/10.5152/balkanmedj.2016.15286
dc.identifier.urihttps://hdl.handle.net/20.500.12491/8760
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TWpBeE1qVTJOZz09
dc.identifier.volume33en_US
dc.identifier.wosWOS:000383206400012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorŞanal, Serap Köybaşı
dc.institutionauthorBiçer, Yusuf Özgür
dc.institutionauthorKükner, Aysel
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPregnancyen_US
dc.subjectvoiceen_US
dc.subjectMast Cellen_US
dc.subjectGlycosaminoglycansen_US
dc.titleEffect of pregnancy on vocal cord histology: an animal experimenten_US
dc.typeArticleen_US

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