Impact of water-soluble zwitterionic Zn(II) phthalocyanines against pathogenic bacteria
dc.authorid | 0000-0001-9258-1866 | en_US |
dc.authorid | 0000-0002-7841-0910 | en_US |
dc.authorid | 0000-0003-0440-7345 | |
dc.authorid | 0000-0001-7704-5520 | |
dc.contributor.author | Mantareva, Vanya | |
dc.contributor.author | Göl, Cem | |
dc.contributor.author | Kussovski, Vesselin | |
dc.contributor.author | Durmuş, Mahmut | |
dc.contributor.author | Angelov, Ivan | |
dc.date.accessioned | 2021-06-23T19:51:27Z | |
dc.date.available | 2021-06-23T19:51:27Z | |
dc.date.issued | 2019 | |
dc.department | BAİBÜ, Rektörlük, Yenilikçi Gıda Teknolojileri Geliştirme Uygulama ve Araştırma Merkezi | en_US |
dc.description.abstract | The photodynamic impact of water-soluble zwitterionic zinc phthalocyanines (ZnPc1-4) was studied on pathogenic bacterial strains after specific light exposure (LED 665 nm). The structural differences between the studied ZnPc1-4 are in the positions and the numbers of substitution groups as well as in the bridging atoms (sulfur or oxygen) between substituents and macrocycle. The three peripherally substituted compounds (ZnPc1-3) are tetra-2-(N-propanesulfonic acid) oxypyridine (ZnPc1), tetra-2-( N-propanesulfonic acid) mercaptopyridine (ZnPc2), and octa-substituted 2-(N-propanesulfonic acid) mercaptopyridine (ZnPc3). The nonperipherally substituted compound is tetra-2-(N-propanesulfonic acid) mercaptopyridine (ZnPc4). The uptake and localization capability are studied on Gram (+) Enterococcus faecalis and Gram (-) Pseudomonas aeruginosa as suspensions and as 48 h biofilms. Relatively high accumulations of ZnPc1-4 show bacteria in suspensions with different cell density. The compounds have complete penetration in E. faecalis biofilms but with nonhomogenous distribution in P. aeruginosa biomass. The cytotoxicity test (Balb/c 3T3 Neutral Red Uptake) with ZnPc1-4 suggests the lack of dark toxicity on normal cells. However, only ZnPc3 has a minimal photocytotoxic effect toward Balb/c 3T3 cells and a comparable high potential in the photoinactivation of pathogenic bacterial species. | en_US |
dc.identifier.doi | 10.1515/znc-2018-0203 | |
dc.identifier.endpage | 191 | en_US |
dc.identifier.issn | 0939-5075 | |
dc.identifier.issn | 1865-7125 | |
dc.identifier.issue | 7-8 | en_US |
dc.identifier.pmid | 31194695 | en_US |
dc.identifier.scopus | 2-s2.0-85067478502 | en_US |
dc.identifier.scopusquality | Q3 | en_US |
dc.identifier.startpage | 183 | en_US |
dc.identifier.uri | https://doi.org/10.1515/znc-2018-0203 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12491/9988 | |
dc.identifier.volume | 74 | en_US |
dc.identifier.wos | WOS:000474398300003 | en_US |
dc.identifier.wosquality | Q4 | en_US |
dc.indekslendigikaynak | Web of Science | en_US |
dc.indekslendigikaynak | Scopus | en_US |
dc.indekslendigikaynak | PubMed | en_US |
dc.institutionauthor | Göl, Cem | |
dc.language.iso | en | en_US |
dc.publisher | Walter De Gruyter Gmbh | en_US |
dc.relation.ispartof | Zeitschrift Fur Naturforschung Section C-A Journal Of Biosciences | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Fluorescence Images | en_US |
dc.subject | Pathogenic Bacteria | en_US |
dc.subject | Photodynamic Therapy | en_US |
dc.subject | water-soluble zwitterionic Zn(II) phthalocyanines | en_US |
dc.title | Impact of water-soluble zwitterionic Zn(II) phthalocyanines against pathogenic bacteria | en_US |
dc.type | Article | en_US |