Impact of water-soluble zwitterionic Zn(II) phthalocyanines against pathogenic bacteria

dc.authorid0000-0001-9258-1866en_US
dc.authorid0000-0002-7841-0910en_US
dc.authorid0000-0003-0440-7345
dc.authorid0000-0001-7704-5520
dc.contributor.authorMantareva, Vanya
dc.contributor.authorGöl, Cem
dc.contributor.authorKussovski, Vesselin
dc.contributor.authorDurmuş, Mahmut
dc.contributor.authorAngelov, Ivan
dc.date.accessioned2021-06-23T19:51:27Z
dc.date.available2021-06-23T19:51:27Z
dc.date.issued2019
dc.departmentBAİBÜ, Rektörlük, Yenilikçi Gıda Teknolojileri Geliştirme Uygulama ve Araştırma Merkezien_US
dc.description.abstractThe photodynamic impact of water-soluble zwitterionic zinc phthalocyanines (ZnPc1-4) was studied on pathogenic bacterial strains after specific light exposure (LED 665 nm). The structural differences between the studied ZnPc1-4 are in the positions and the numbers of substitution groups as well as in the bridging atoms (sulfur or oxygen) between substituents and macrocycle. The three peripherally substituted compounds (ZnPc1-3) are tetra-2-(N-propanesulfonic acid) oxypyridine (ZnPc1), tetra-2-( N-propanesulfonic acid) mercaptopyridine (ZnPc2), and octa-substituted 2-(N-propanesulfonic acid) mercaptopyridine (ZnPc3). The nonperipherally substituted compound is tetra-2-(N-propanesulfonic acid) mercaptopyridine (ZnPc4). The uptake and localization capability are studied on Gram (+) Enterococcus faecalis and Gram (-) Pseudomonas aeruginosa as suspensions and as 48 h biofilms. Relatively high accumulations of ZnPc1-4 show bacteria in suspensions with different cell density. The compounds have complete penetration in E. faecalis biofilms but with nonhomogenous distribution in P. aeruginosa biomass. The cytotoxicity test (Balb/c 3T3 Neutral Red Uptake) with ZnPc1-4 suggests the lack of dark toxicity on normal cells. However, only ZnPc3 has a minimal photocytotoxic effect toward Balb/c 3T3 cells and a comparable high potential in the photoinactivation of pathogenic bacterial species.en_US
dc.identifier.doi10.1515/znc-2018-0203
dc.identifier.endpage191en_US
dc.identifier.issn0939-5075
dc.identifier.issn1865-7125
dc.identifier.issue7-8en_US
dc.identifier.pmid31194695en_US
dc.identifier.scopus2-s2.0-85067478502en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage183en_US
dc.identifier.urihttps://doi.org/10.1515/znc-2018-0203
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9988
dc.identifier.volume74en_US
dc.identifier.wosWOS:000474398300003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGöl, Cem
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofZeitschrift Fur Naturforschung Section C-A Journal Of Biosciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFluorescence Imagesen_US
dc.subjectPathogenic Bacteriaen_US
dc.subjectPhotodynamic Therapyen_US
dc.subjectwater-soluble zwitterionic Zn(II) phthalocyaninesen_US
dc.titleImpact of water-soluble zwitterionic Zn(II) phthalocyanines against pathogenic bacteriaen_US
dc.typeArticleen_US

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