The effect of different dialysis membranes on oxidative stress and selenium status

dc.authorid0000-0003-1937-9244
dc.authorid0000-0003-4740-2333
dc.authorid0000-0002-1854-9953
dc.contributor.authorYavuz, Özlem
dc.contributor.authorBicik, Zerrin
dc.contributor.authorÇınar, Yelda
dc.contributor.authorGüney, Yıldız
dc.contributor.authorGüler, Selver
dc.date.accessioned2021-06-23T19:17:53Z
dc.date.available2021-06-23T19:17:53Z
dc.date.issued2004
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.departmentBAİBÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractBackground: Oxidative stress is an important risk factor for the development and progression of several complications in hemodialysis patients. The aim of this study was to evaluate the effects of two different dialysis membranes on oxidative stress and selenium status. Methods: Forty long-term dialysis patients and 20 age-matched healthy controls were enrolled into our study. Serum malondialdehyde (MDA) and selenium (Se) concentrations, and glutathione peroxidase (GSH-Px) activities were determined before and after hemodialysis (HD) using a hemophan (H) or a polysulfone (PS) membrane. Results: MEA levels in the HD patients were significantly higher than those in the control group (p < 0.001). GSH-Px activity and selenium concentrations were significantly lower in HD patients compared to the control group (p < 0.001). MDA levels were significantly increased (p < 0.05); GSH-Px activity and selenium concentrations were significantly reduced (p < 0.001) in the PS membrane group compared to H membrane group after HD. Conclusions: Comparing with H membrane, PS membrane caused more oxidative stress and lower levels of Se in HD patients.en_US
dc.identifier.doi10.1016/j.cccn.2004.03.025
dc.identifier.endpage160en_US
dc.identifier.issn0009-8981
dc.identifier.issue2en_US
dc.identifier.pmid15256316en_US
dc.identifier.scopus2-s2.0-3142598576en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage153en_US
dc.identifier.urihttps://doi.org/10.1016/j.cccn.2004.03.025
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5575
dc.identifier.volume346en_US
dc.identifier.wosWOS:000223042700006en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYavuz, Özlem
dc.institutionauthorBicik, Zerrin
dc.institutionauthorÇınar, Yelda
dc.institutionauthorGüler, Selver
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofClinica Chimica Actaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHemodialysisen_US
dc.subjectReactive Oxygen Speciesen_US
dc.subjectOxidative Stressen_US
dc.subjectHemophan Membraneen_US
dc.subjectPolysulfone Membraneen_US
dc.subjectSeleniumen_US
dc.titleThe effect of different dialysis membranes on oxidative stress and selenium statusen_US
dc.typeArticleen_US

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