The evaluation of topical administration of Bellis perennis fraction on circular excision wound healing in Wistar albino rats

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dc.authorid0000-0003-3911-6388en_US
dc.authorid0000-0001-5245-6294
dc.authorid0000-0001-9617-6673
dc.contributor.authorKarakaş, Fatma Pehlivan
dc.contributor.authorKarakaş, Alper
dc.contributor.authorBoran, Çetin
dc.contributor.authorTürker, Arzu Uçar
dc.contributor.authorYalçın, Funda Nuray
dc.contributor.authorBilensoy, Erem
dc.date.accessioned2021-06-23T19:29:24Z
dc.date.available2021-06-23T19:29:24Z
dc.date.issued2012
dc.departmentBAİBÜ, Fen Edebiyat Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractContext: Bellis perennis L. (Asteraceae) has been used traditionally in the treatment of bruises, broken bones, and wounds by European people. Objective: To investigate the wound healing activity of B. perennis flowers in Wistar albino rats. Materials and methods: Dried B. perennis flowers were extracted with ethanol, then fractioned with n-butanol and an oinment was prepared. Twelve male adult Wistar rats were used. Six wounds were created for each animal by using circular excision wound model. The first two wounds were treated topically with HOTBp (hydrophilic ointment treatment containing n-butanol fraction). The second two wounds were control group and not treated with anything. The third two wounds were treated only with HOT (hydrophilic ointment treatment without n-butanol fraction). Treatments were applied once a day and lasted for 30 days. Wound samples were excised on days 5th, 10th and 30th. The percentage of wound healing was calculated by Walker's formula after measurement of the wound area and the tissue samples were examined histopathologically. Results: The percentages of wound closure (HOTBp: 100%; HOT: 85% and control: 87%) and histopathological observations showed that there were statistically significant differences between HOTBp, HOT and control groups (p < 0.05) at 30th day. Discussion and conclusion: Topically administered ointment prepared from the n-butanol fraction of B. perennis flowers has a wound healing potential without scar formation in circular excision wound model in rats. Thus, traditional usage of wound healing activity of B. perennis was scientifically verified for the first time.en_US
dc.identifier.doi10.3109/13880209.2012.656200
dc.identifier.endpage1037en_US
dc.identifier.issn1388-0209
dc.identifier.issn1744-5116
dc.identifier.issue8en_US
dc.identifier.pmid22775421en_US
dc.identifier.scopus2-s2.0-84863678162en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1031en_US
dc.identifier.urihttps://doi.org/10.3109/13880209.2012.656200
dc.identifier.urihttps://hdl.handle.net/20.500.12491/7167
dc.identifier.volume50en_US
dc.identifier.wosWOS:000306191700013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKarakaş, Fatma Pehlivan
dc.institutionauthorKarakaş, Alper
dc.institutionauthorBoran, Çetin
dc.institutionauthorTürker, Arzu Uçar
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofPharmaceutical Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCommon Daisyen_US
dc.subjectN-butanol Fractionen_US
dc.subjectOintmenten_US
dc.titleThe evaluation of topical administration of Bellis perennis fraction on circular excision wound healing in Wistar albino ratsen_US
dc.typeArticleen_US

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