Serum visfatin, adiponectin, and tumor necrosis factor alpha (TNF-alpha) levels in patients with psoriasis and their correlation with disease severity

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dc.authorid0000-0002-4060-3354en_US
dc.authorid0000-0001-9947-7690
dc.authorid0000-0001-6745-4849
dc.authorid0000-0001-9226-5134
dc.authorid0000-0001-5515-3811
dc.contributor.authorŞereflican, Betül
dc.contributor.authorGöksugur, Nadir
dc.contributor.authorBuğdaycı, Güler
dc.contributor.authorPolat, Mualla
dc.contributor.authorParlak, Ali Haydar
dc.date.accessioned2021-06-23T19:44:34Z
dc.date.available2021-06-23T19:44:34Z
dc.date.issued2016
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractPsoriasis is a chronic, autoimmune, and inflammatory disease of unknown etiology, characterized by T lymphocyte mediated keratinocyte proliferation. In recent years the relationship between psoriasis and adipose tissue cytokines has been reported. Psoriasis as a triggering factor for the immune and metabolic disorders can be associated with diabetes mellitus, abnormal lipid metabolism, and metabolic syndrome. In this study we assessed the adipose tissue cytokines visfatin, adiponectin, and tumor necrosis factor-alpha (TNF-alpha) levels in psoriasis patients and evaluated the relationship between disease severity and cytokines. The study included 42 patients with psoriasis and 42 healthy individuals. Visfatin, adiponectin, and TNF-alpha levels were measured in both the psoriasis and the control group. The disease severity index was assessed in psoriatic patients by means of PASI. The relationship between visfatin, adiponectin, TNF-alpha, PASI score, and obesity was evaluated. When serum TNF-alpha, adiponectin, and visfatin levels of the patient group were compared with those of the control group, the TNF-alpha levels were statistically higher (p = 0.00) and the adiponectin levels were statistically lower (p = 0.024). The visfatin levels were higher in the psoriatic patients compared to the control group, but this difference was not statistically significant (p = 0.73). The relationship between PASI-TNF-alpha and between PASI-adiponectin was statistically significant (p = 0.009 and p = 0.004). A positive correlation was observed between body mass index (BMI) and visfatin (p = 0.031). These results indicate that TNF-alpha and adiponectin play a part in psoriasis etiopathogenesis and can be used as parameters to evaluate the severity of the disease. However, the role of visfatin in psoriasis pathogenesis is unclear. Further clinical studies are needed to clarify the effect of visfatin in psoriatic patients.en_US
dc.identifier.endpage19en_US
dc.identifier.issn1330-027X
dc.identifier.issn1847-6538
dc.identifier.issue1en_US
dc.identifier.pmid27149125en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage13en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12491/9007
dc.identifier.urihttps://www.webofscience.com/wos/woscc/full-record/WOS:000375359800003
dc.identifier.volume24en_US
dc.identifier.wosWOS:000375359800003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorŞereflican, Betül
dc.institutionauthorGöksugur, Nadir
dc.institutionauthorBuğdaycı, Güler
dc.institutionauthorPolat, Mualla
dc.institutionauthorParlak, Ali Haydar
dc.language.isoenen_US
dc.publisherCroation Dermatovenerological Socen_US
dc.relation.ispartofActa Dermatovenerologica Croaticaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPsoriasisen_US
dc.subjectAdipokinesen_US
dc.subjectObesityen_US
dc.subjectAdiponectinen_US
dc.subjectTNF-alphaen_US
dc.subjectVisfatinen_US
dc.titleSerum visfatin, adiponectin, and tumor necrosis factor alpha (TNF-alpha) levels in patients with psoriasis and their correlation with disease severityen_US
dc.typeArticleen_US

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