Evaluation of dysfunctional high-density lipoprotein levels with myeloperoxidase/paraoxonase-1 ratio in rheumatoid arthritis

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dc.authorid0000-0003-1856-9513en_US
dc.authorid0000-0002-9163-2569en_US
dc.authorid0000-0003-0434-3206en_US
dc.authorid0000-0001-6906-991Xen_US
dc.authorid0000-0003-2573-4564en_US
dc.authorid0000-0002-2996-3236en_US
dc.contributor.authorAlışık, Tuğba
dc.contributor.authorAlışık, Murat
dc.contributor.authorNacır, Barış
dc.contributor.authorAyhan, Fikriye Figen
dc.contributor.authorGenç, Hakan
dc.contributor.authorErel, Özcan
dc.date.accessioned2023-06-20T07:30:13Z
dc.date.available2023-06-20T07:30:13Z
dc.date.issued2021en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground The aim of this study is to evaluate dysfunctional high-density lipoprotein cholesterol (HDL) by measuring myeloperoxidase (MPO)/paraoxonase 1 (PON1) ratio in patients with rheumatoid arthritis (RA) and to investigate the relationship between dysfunctional HDL and cardiovascular disease (CVD) in RA patients. Methods Sixty-seven healthy individuals and 130 RA patients were included in the study. Routine lipid panels (triglyceride (TG), low-density lipoprotein cholesterol (LDL), HDL, total cholesterol (TC), PON1 and MPO levels were measured. Disease activity scores-28 (DAS28) of RA patients were calculated. Cardiological examination records of the patients were assessed to detect patients who also have CVD. Results There were no significant differences between RA and control groups in routine lipid profiles (P > .05 for all). MPO/PON1 ratios were significantly elevated in the RA group compared with the control group (P < .001). MPO/PON1 ratios were higher in RA patients with CVD history compared with those without CVD (P < .05). MPO/PON1 ratios were correlated with DAS28 scores (rho: 0.357, P < .001). Conclusion HDL dysfunction determined by the MPO/PON1 ratio may be associated with the pathophysiology of increased CVD in RA. Thus, evaluating dysfunctional HDL levels by measuring the MPO/PON1 ratio in RA patients may allow more detailed patient follow-up, as well as the reduction of CVD events in RA patients with therapeutic agents aiming to increase the functional properties of HDL by decreasing this ratio.en_US
dc.identifier.citationAlisik, T., Alisik, M., Nacir, B., Ayhan, F. F., Genc, H., & Erel, O. (2021). Evaluation of dysfunctional high‐density lipoprotein levels with myeloperoxidase/paraoxonase‐1 ratio in rheumatoid arthritis. International Journal of Clinical Practice, 75(7), e14172.en_US
dc.identifier.doi10.1111/ijcp.14172
dc.identifier.endpage7en_US
dc.identifier.issn1368-5031
dc.identifier.issn1742-1241
dc.identifier.issue7en_US
dc.identifier.pmid33756027en_US
dc.identifier.scopus2-s2.0-85103211952en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttp://dx.doi.org/10.1111/ijcp.14172
dc.identifier.urihttps://hdl.handle.net/20.500.12491/11146
dc.identifier.volume75en_US
dc.identifier.wosWOS:000634228800001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAlışık, Tuğba
dc.institutionauthorAlışık, Murat
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternational Journal of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHigh-Density Lipoprotein Cholesterol (HDL)en_US
dc.subjectMPO/PON1en_US
dc.subjectHDLen_US
dc.titleEvaluation of dysfunctional high-density lipoprotein levels with myeloperoxidase/paraoxonase-1 ratio in rheumatoid arthritisen_US
dc.typeArticleen_US

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