C-reactive protein to albumin ratio in patients with prediabetes and diabetes mellitus: HbA1c and inflammation

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dc.authorid0000-0001-6262-6103en_US
dc.authorid0000-0003-0434-3206en_US
dc.authorid0000-0002-7006-3125en_US
dc.contributor.authorDemirkol, Muhammed Emin
dc.contributor.authorAlışık, Murat
dc.contributor.authorYis, Özgür Mehmet
dc.date.accessioned2023-05-12T06:07:28Z
dc.date.available2023-05-12T06:07:28Z
dc.date.issued2022en_US
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Inflammation has a significant status in both the pathogenesis and complications of diabetes mellitus (DM). The aim of this study is to compare the C-reactive protein (CRP) to albumin ratio (CAR) values in controlled DM, uncontrolled DM, prediabetes groups grouped by HbA1c as well as in a group of healthy individuals. Methods: In this retrospective study, 6,993 DM patients, 770 prediabetes patients, and 1,340 healthy individuals were included. According to their HbA1c levels, DM patients were divided into two groups as controlled DM (HbAlc < 6.5%, n = 4,115) and uncontrolled DM (HbAlc ??? 6.5%, n = 2,878). Results: The CRP and CAR levels were significantly higher in the DM and prediabetes group than in the control group (p < 0.05, for both). Albumin levels were significantly lower in the DM group than in both the prediabetes and control groups (p < 0.05, for both). In the uncontrolled DM group, CRP and CAR values were found to be significantly higher than the control and controlled DM groups, while albumin values were significantly lower than the control group, prediabetes group, and controlled DM group (p < 0.05, for all). Conclusions: It is thought that CAR, a liver related inflammatory marker, can be applied as an inflammation marker in both prediabetes, determined by HbA1c, and patients diagnosed with DM. Further prospective studies will better demonstrate the utility of CAR values as an inflammatory marker in DM and prediabetes.en_US
dc.identifier.citationDemirkol, M. E., Alisik, M., & Yis, O. M. (2022). C-reactive protein to albumin ratio in patients with prediabetes and diabetes mellitus: HbA1c and inflammation. Clinical Laboratory, 68(8).en_US
dc.identifier.doi10.7754/Clin.Lab.2021.211108
dc.identifier.endpage1694en_US
dc.identifier.issn1433-6510
dc.identifier.issue8en_US
dc.identifier.pmid35975507en_US
dc.identifier.scopus2-s2.0-85135948970en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1688en_US
dc.identifier.urihttp://dx.doi.org/10.7754/Clin.Lab.2021.211108
dc.identifier.urihttps://hdl.handle.net/20.500.12491/10867
dc.identifier.volume68en_US
dc.identifier.wosWOS:000835268800001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDemirkol, Muhammed Emin
dc.institutionauthorAlışık, Murat
dc.institutionauthorYis, Özgür Mehmet
dc.language.isoenen_US
dc.publisherClinical Laboratory Publicationen_US
dc.relation.ispartofClinical Laboratoryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPrediabetesen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectC-Reactive Proteinen_US
dc.subjectProtein/Albumin Ratioen_US
dc.subjectAssociationen_US
dc.subjectMarkersen_US
dc.titleC-reactive protein to albumin ratio in patients with prediabetes and diabetes mellitus: HbA1c and inflammationen_US
dc.typeArticleen_US

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