The effects of the intraamygdalar melatonin injections on the anxiety like behavior and the spatial memory performance in male Wistar rats

dc.authorid000-0002-5509-8717
dc.authorid0000-0001-9316-9574
dc.contributor.authorKarakaş, Alper
dc.contributor.authorCoşkun, Hamit
dc.contributor.authorKaya, Aliye
dc.contributor.authorKüçük, Ayşegül
dc.contributor.authorGündüz, Bülent
dc.date.accessioned2021-06-23T19:27:41Z
dc.date.available2021-06-23T19:27:41Z
dc.date.issued2011
dc.departmentBAİBÜ, Fen Edebiyat Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractIn the present study, the effects of intraamygdalar administrations of melatonin (1 and 100 mu g/kg), saline and diazepam on the anxiety-like behavior and spatial memory performance in pinealectomized and sham-pinealectomized Wistar rats were investigated. The animals were tested by open field and elevated plus maze tests for anxiety-like behavior, and Morris water maze test for spatial memory. In open field, (a) diazepam was more effective in reducing the anxiety, (b) control subjects were more mobile than pinealectomized subjects and (c) 100 mu g/kg melatonin administrations reduced the velocity of the animals. In elevated plus maze, (a) 100 mu g/kg melatonin administrations increased the distance totally travelled and (b) enhanced the time spent in open arms, however, after the pinealectomy, 1 mu g/kg melatonin administrations decreased it and (c) control animals were less mobile than pinealectomized ones. In Morris water maze, (a) diazepam group travelled more distance than the others in control condition whereas, in pinealectomy condition high dose of melatonin and saline groups travelled more distance than the others, (b) in pinealectomy condition subjects who received 100 mu g/kg melatonin also travelled more distance than those who received 1 mu g/kg melatonin and diazepam, (c) the subjects who received 1 mu g/kg spent less time than those who received other treatments, and (d) in control condition subjects who received 100 mu g/kg melatonin were slower than those who received the other treatments. In conclusion, melatonin administration to amygdala decreased the anxiety; however, spatial memory performance of the rats was impaired by the pinealectomy and melatonin administrations. (C) 2011 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.bbr.2011.03.029
dc.identifier.endpage150en_US
dc.identifier.issn0166-4328
dc.identifier.issn1872-7549
dc.identifier.issue1en_US
dc.identifier.pmid21421010en_US
dc.identifier.scopus2-s2.0-79955786175en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage141en_US
dc.identifier.urihttps://doi.org/10.1016/j.bbr.2011.03.029
dc.identifier.urihttps://hdl.handle.net/20.500.12491/6872
dc.identifier.volume222en_US
dc.identifier.wosWOS:000291418400018en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKarakaş, Alper
dc.institutionauthorCoşkun, Hamit
dc.institutionauthorKaya, Aliye
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofBehavioural Brain Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPineal Glanden_US
dc.subjectMelatoninen_US
dc.subjectAmygdalaen_US
dc.subjectAnxietyen_US
dc.subjectMemoryen_US
dc.titleThe effects of the intraamygdalar melatonin injections on the anxiety like behavior and the spatial memory performance in male Wistar ratsen_US
dc.typeArticleen_US

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