Neonatal screening for congenital hypothyroidism in West Black Sea area, Turkey

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dc.authorid0000-0003-0120-9976
dc.authorid0000-0001-7105-7176
dc.authorid0000-0002-4030-1145
dc.contributor.authorŞimşek, Enver
dc.contributor.authorKarabay, Meltem
dc.contributor.authorKocabay, Kenan
dc.date.accessioned2021-06-23T19:18:31Z
dc.date.available2021-06-23T19:18:31Z
dc.date.issued2005
dc.departmentBAİBÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractThe aim of this study was to investigate the incidence of congenital hypothyroidism (CH) in the West Black Sea Area, a mild-to-moderate iodine deficient area in Turkey. Neonatal screening for CH was performed using blood specimens collected onto filter paper. Thyrotropin [thyroid-stimulating hormone (TSH)] was measured by radioimmunoassay, and a value >20 mu U/ml was considered as cut-off point for re-examining. Venous serum was obtained to measure TSH, thyroxin (T4), free T4 (FT4) and thyroglobulin (TG). To determine the iodine status of the study area, median urinary iodine was measured in 212 randomly selected neonates and their mothers. A total of 18606 neonates were screened from three cities (Bolu, Duzce, and Zonguldak) between 2000 and 2002. With a cut-off point of TSH value >20 mu U/ml, the recall rate was found 1.6%. Eight cases of CH were diagnosed (incidence 1/2,326).There were three cases of transient hypothyroldism, with an incidence of 1/6202. Twenty-six percent of the TSH values was greater than 5 mu U/ml. Median urinary iodine concentrations in neonates and their mothers were 85 mu g/l and 40 mu g/l, respectively. The incidences of CH, transient hypochyroidism and the recall rate were higher in our study area than many countries in Europe. The study area has been affected by mild-to-moderate iodine deficiency. Neonatal screening for CH should be introduced in Turkey without delay. A national comprehensive infantile hypothyroidism and iodine prophylaxis policies should be developed.en_US
dc.identifier.doi10.1111/j.1368-5031.2005.00222.x
dc.identifier.endpage341en_US
dc.identifier.issn1368-5031
dc.identifier.issue3en_US
dc.identifier.pmid15857333en_US
dc.identifier.scopus2-s2.0-14844342300en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage336en_US
dc.identifier.urihttps://doi.org/10.1111/j.1742-1241.2004.00222.x
dc.identifier.urihttps://hdl.handle.net/20.500.12491/5749
dc.identifier.volume59en_US
dc.identifier.wosWOS:000227556400016en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorŞimşek, Enver
dc.institutionauthorKarabay, Meltem
dc.institutionauthorKocabay, Kenan
dc.language.isoenen_US
dc.publisherBlackwell Publishing Ltden_US
dc.relation.ispartofInternational Journal Of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCongenital Hypothyroidismen_US
dc.subjectScreeningen_US
dc.subjectIodine Deficiencyen_US
dc.titleNeonatal screening for congenital hypothyroidism in West Black Sea area, Turkeyen_US
dc.typeArticleen_US

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